A CYTOLOGICAL AND HISTOPATHOLOGICAL CORRELATIVE STUDY ON NEOPLASTIC LESIONS WITH MILAN SYSTEM FOR REPORTING SALIVARY GLAND CYTOPATHOLOGY.

Q3 Medicine

Experimental oncology Pub Date : 2022-11-01 DOI:10.32471/exp-oncology.2312-8852.vol-44-no-3.18577

B Sridevi, R Veena, G Shivashekar, R Bhuvanamha Devi, M Aswin Manikandan, P Vineetha, S Dinesh

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引用次数: 0

Abstract

Background: Salivary gland tumors are rare. Nevertheless, the accurate preoperative diagnosis of the malignant potential of the lesion is essential for appropriate patient management. The recently published Milan system for reporting salivary gland cytology (MSRSGC) is an effort to provide better communication regarding the nature of lesions to clinicians. Aim: To evaluate the diagnostic utility of fine-needle aspiration cytology (FNAC) of neoplastic salivary gland lesions and the MSRSGC applicability in risk stratification.

Materials and methods: This was a retrospective study of the cytological and histopathological correlation between neoplastic lesions of salivary gland lesions conducted over four years (August 2010 - September 2014) in two tertiary care hospitals. There were 66 cases of FNAC of salivary gland neoplasms. The sensitivity, specificity, positive predictive value, negative predictive value, and overall diagnostic accuracy of FNAC were analyzed. The risk of malignancy for MSRSGC was calculated.

Results: The overall diagnostic accuracy, sensitivity, specificity, and positive and negative predictive values were 93.94; 95.5; 99.8; 96.8, and 98.7%, respectively. By correlating the cytological diagnosis of benign neoplasm with histopathological diagnosis, the risk of malignancy was 0% and risk of neoplasm was 100%. For cases in the category suspicious of malignancy, risk of neoplasm was 100% and risk of malignancy was 85%.

Conclusion: The present study demonstrated that this salivary gland cytology reporting system was useful in classifying the lesions in well-delineated categories with ease. MSRSGC system of standardized reporting is helpful for guiding clinicians in appropriate management of the patient. However, many multicenter studies with large sample sizes and long-term follow-up are needed along with wide propagation of its standardized reporting format to be adopted universally.

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用米兰系统报道唾液腺细胞病理学对肿瘤病变的细胞学和组织病理学相关性研究。

背景:唾液腺肿瘤是罕见的。然而，准确的术前诊断病变的恶性潜能是必要的适当的病人管理。最近发布的报告唾液腺细胞学的米兰系统(MSRSGC)是一项努力，为临床医生提供关于病变性质的更好的沟通。目的:评价细针穿刺细胞学(FNAC)对肿瘤涎腺病变的诊断价值及MSRSGC在危险分层中的适用性。材料与方法:回顾性研究两家三级医院(2010年8月- 2014年9月)4年间涎腺肿瘤病变的细胞学与组织病理学相关性。涎腺肿瘤FNAC 66例。分析FNAC的敏感性、特异性、阳性预测值、阴性预测值及总体诊断准确率。计算MSRSGC的恶性风险。结果:总体诊断准确率、敏感性、特异性、阳性预测值和阴性预测值为93.94;95.5;99.8;分别为96.8和98.7%。将良性肿瘤的细胞学诊断与组织病理学诊断相比较，恶性肿瘤的风险为0%，肿瘤的风险为100%。怀疑为恶性的病例，发生肿瘤的风险为100%，恶性的风险为85%。结论:本研究表明，该唾液腺细胞学报告系统可方便地将病变划分为清晰的类别。MSRSGC系统的规范化报告有助于指导临床医生对患者进行合理的管理。但是，还需要大量的多中心、大样本量、长期随访的研究，以及其标准化报告格式的广泛传播，以便被普遍采用。

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来源期刊

Experimental oncology Medicine-Oncology

CiteScore

1.40

自引率

0.00%

发文量

期刊介绍： The Experimental Oncology is an English-language journal that publishes review articles, original contributions, short communications, case reports and technical advances presenting new data in the field of experimental and fundamental oncology. Manuscripts should be written in English, contain original work, which has not been published or submitted for publication elsewhere. It also implies the transfer of the Copyright from the author to “Experimental Oncology”. No part of journal publications may be reproduced, stored in a retrieval system or transmitted in any form or by any means without the prior permission of the publisher.