Dose-response analysis of aripiprazole in patients with schizophrenia in Taiwan.

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC

ACS Applied Electronic Materials Pub Date : 2022-07-30 eCollection Date: 2022-01-01 DOI:10.1177/20451253221113238

Yun Tien, Hsiang-Ping Huang, Ding-Lieh Liao, Shang-Chien Huang

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引用次数: 2

Abstract

Background: Aripiprazole is a third-generation antipsychotic agent with acceptable efficacy and a good safety profile. Previous studies have indicated the therapeutic serum concentration of aripiprazole to be 100 to 350 ng/ml; however, most of these studies examined a Western population. Patients with schizophrenia from Tungs' Taichung MetroHarbor Hospital in central Taiwan were recruited to analyze the dose-response relationship of aripiprazole in the Chinese population.

Objective: We aimed to investigate whether a serum concentration of aripiprazole higher than the current suggested range leads to higher response rates.

Design: A prospective cohort study was designed to investigate the response rates in different studied cohorts grouped by serum concentration of aripiprazole.

Data sources and methods: Data of 64 patients who presented to a single medical center in central Taiwan and who received therapeutic drug monitoring (TDM) were obtained. Serum concentrations of aripiprazole were correlated with the clinical response of patients by using the Clinical Global Impressions (CGI) scores.

Results: The mean concentration of aripiprazole was 432.1 ± 275.1 ng/ml in the study cohort. Among the much-improved patients, the mean serum concentration of aripiprazole was 494 ± 273 ng/ml (25th-75th percentiles 264-666 ng/ml), which was higher than the current recommended therapeutic target of 100-350 ng/ml for aripiprazole. The response rate in the severe group (baseline CGI score of 6 or 7) was significantly higher than in the moderate group (baseline CGI score of 4 or 5; 86.7% versus 55.9%, p = 0.007).

Conclusion: A significantly higher response rate was observed in the study cohort with serum aripiprazole concentrations over 300 ng/ml. Therefore, dosing higher than the current recommended range may potentially improve the treatment efficacy in the Chinese population. Because the serum concentration varies among patients due to multiple intrinsic and extrinsic factors, TDM, especially in outpatients, is recommended if the clinical response is limited.

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阿立哌唑对台湾精神分裂症患者的剂量-反应分析。

背景:阿立哌唑是第三代抗精神病药物，具有可接受的疗效和良好的安全性。既往研究表明阿立哌唑治疗性血清浓度为100 ~ 350 ng/ml;然而，这些研究大多是针对西方人群的。本研究从台湾中部的台中港大都会医院招募精神分裂症患者，分析阿立哌唑在中国人群中的剂量-反应关系。目的:我们的目的是研究阿立哌唑的血清浓度是否高于目前建议的范围导致更高的应答率。设计:设计一项前瞻性队列研究，以阿立哌唑的血清浓度为分组，调查不同研究队列的应答率。资料来源与方法:收集台湾中部单一医疗中心接受治疗药物监测(TDM)的64例患者资料。使用临床总体印象(CGI)评分将阿立哌唑的血清浓度与患者的临床反应相关联。结果:研究队列中阿立哌唑平均浓度为432.1±275.1 ng/ml。在病情好转的患者中，阿立哌唑的平均血清浓度为494±273 ng/ml(25 -75百分位数264-666 ng/ml)，高于目前推荐的阿立哌唑治疗目标100-350 ng/ml。重度组(基线CGI评分为6或7分)的有效率显著高于中度组(基线CGI评分为4或5分;86.7%对55.9%，p = 0.007)。结论:血清阿立哌唑浓度超过300 ng/ml的研究队列应答率显著提高。因此，高于目前推荐范围的剂量可能会潜在地改善中国人群的治疗效果。由于患者的血清浓度因多种内在和外在因素而存在差异，因此在临床反应有限的情况下，推荐使用TDM，尤其是门诊患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Electronic Materials Multiple-

CiteScore

7.20

自引率

4.30%

发文量

567

期刊介绍： ACS Applied Electronic Materials is an interdisciplinary journal publishing original research covering all aspects of electronic materials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials science, engineering, optics, physics, and chemistry into important applications of electronic materials. Sample research topics that span the journal's scope are inorganic, organic, ionic and polymeric materials with properties that include conducting, semiconducting, superconducting, insulating, dielectric, magnetic, optoelectronic, piezoelectric, ferroelectric and thermoelectric. Indexed/Abstracted： Web of Science SCIE Scopus CAS INSPEC Portico