Patient Characteristics Associated with the Development of Oral Lichen Planus in Two Provinces in Canada.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2022-07-01

Shiri Iskander, Firoozeh Samim

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引用次数: 0

Abstract

Objectives: To understand the risk factors that may be associated with the development of oral lichen planus (OLP) and its progression.

Study design: We conducted retrospective chart reviews of adult patients with OLP who presented to oral medicine and oral pathology clinics in 2 provinces between September 2016 and January 2020. Data regarding age, sex, disease duration, sites of involvement, comorbidities, medications, allergies, smoking, alcohol use, treatment and follow up were collected. Descriptive statistics were assessed.

Results: Among the 94 patients with OLP, mean age was 62 years and most were female (73%). Mean disease duration was 3.1 years. Hypertension, thyroid disorders and diabetes were present in 32%, 28% and 17% of patients, respectively. A significant proportion of patients reported a major surgical procedure (47%) as a preceding event and an additional 7% reported a preceding stressful life event. Three OLP patients (3%) developed squamous cell carcinoma or dysplasia. The mean disease duration for these patients was 4.06 years and the frequency of biopsy in our study was approximately 14%.

Conclusions: Female sex, endocrine and immunological comorbidities, such as thyroid disease and diabetes, and psychological stress may play a role in the development of OLP in the Canadian population. A small percentage of patients may develop malignant transformation and, thus, require long-term monitoring.

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加拿大两个省口腔扁平苔藓发展的患者特征

目的:了解可能与口腔扁平苔藓(OLP)发生及其进展相关的危险因素。研究设计:我们对2016年9月至2020年1月在2个省口腔医学和口腔病理诊所就诊的成年OLP患者进行回顾性图表回顾。收集有关年龄、性别、疾病持续时间、发病部位、合并症、药物、过敏、吸烟、饮酒、治疗和随访的数据。描述性统计进行评估。结果94例OLP患者中，平均年龄62岁，以女性居多(73%)。平均病程为3.1年。高血压、甲状腺疾病和糖尿病分别在32%、28%和17%的患者中存在。相当大比例的患者(47%)报告了之前的大手术过程，另外7%的患者报告了之前的压力生活事件。3例OLP患者(3%)发展为鳞状细胞癌或不典型增生。这些患者的平均病程为4.06年，在我们的研究中活检的频率约为14%。结论:女性、内分泌和免疫合并症，如甲状腺疾病和糖尿病，以及心理压力可能在加拿大人群中OLP的发展中发挥作用。一小部分患者可能发生恶性转化，因此需要长期监测。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.