Association between carotid intima-media thickness and acute kidney injury following isolated coronary artery bypass surgery.

IF 0.7 4区医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiovascular Journal of Africa Pub Date : 2023-09-23 Epub Date: 2022-08-01 DOI:10.5830/CVJA-2022-035

Çağrı Düzyol, Hüseyin Şaşkin

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引用次数: 0

Abstract

Objective: The association between pre-operative carotid intima-media thickness (CIMT) and early postoperative acute kidney injury (AKI) following isolated coronary artery bypass grafting (CABG) was investigated.

Methods: Data were sought retrospectively of 237 patients (166 male, 71 female; mean age 61.4 ± 8.1 years; range: 32-74), operated on for isolated CABG with cardiopulmonary bypass (CPB) in a single centre between June 2014 and December 2020, with a serum creatinine level < 1.5 mg/dl and normal carotid arteries on Doppler ultrasonography. AKI diagnosis was made according to the Kidney Disease Improving Global Outcomes 2012 Acute Kidney Injury Guideline. Patients were grouped as group 1 with AKI in the early postoperative period (n = 63) and group 2 without AKI ( n = 174). Univariate analyses were done to determine significant clinical factors, and subsequent multiple logistic regression analysis was done to determine independent predictors of AKI.

Results: AKI occurred in 63 (26.6%) patients. Pre-operative CIMT was significantly higher in the AKI group (p = 0.0001). Multivariate logistic regression analysis revealed that elevated pre-operative CIMT ( p = 0.005), C-reactive protein ( p = 0.001), erythrocyte sedimentation rate ( p = 0.005), neutrophil-lymphocyte ratio ( p = 0.0001) and platelet-lymphocyte ratio ( p = 0.0001) increased on the postoperative seventh day. C-reactive protein ( p = 0.04), postoperative first day platelet- lymphocyte ratio ( p = 0.0001), postoperative seventh day erythrocyte sedimentation rate ( p = 0.02) and intubation time ( p = 0.02) were independent predictors of early postoperative AKI following isolated CABG.

Conclusions: Pre-operative CIMT was found to be an independent predictor of AKI in the early postoperative period of isolated CABG.

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颈动脉内膜中层厚度与孤立性冠状动脉搭桥术后急性肾损伤的关系。

目的：探讨术前颈动脉内膜-中膜厚度（CIMT）与术后早期急性肾损伤（AKI）的关系。方法：回顾性分析237名患者（166名男性，71名女性；平均年龄61.4±8.1岁；范围：32-74岁）的数据，这些患者于2014年6月至2020年12月在一个中心接受了体外循环（CPB）孤立性冠状动脉旁路移植术，血清肌酐水平<1.5 mg/dl，多普勒超声显示颈动脉正常。AKI的诊断是根据《2012年肾脏疾病改善全球结果急性肾损伤指南》进行的。患者分为术后早期有AKI的第一组（n=63）和无AKI的第二组（n=174）。进行单变量分析以确定重要的临床因素，随后进行多元逻辑回归分析以确定AKI的独立预测因素。结果：AKI患者63例（26.6%）。AKI组术前CIMT显著升高（p=0.0001）。多因素logistic回归分析显示，术后第7天，术前CIMT升高（p=0.005）、C反应蛋白升高（p=0.001）、红细胞沉降率升高（p=0.0005）、中性粒细胞淋巴细胞比率升高（p=0.0001）和血小板淋巴细胞比率升高。C反应蛋白（p=0.04）、术后第1天血小板-淋巴细胞比率（p=0.0001）、术前第7天红细胞沉降率（p=0.02）和插管时间（p=0.002）是单独CABG术后早期AKI的独立预测因素。结论：术前CIMT是孤立性冠状动脉旁路移植术后早期AKI的独立预测指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cardiovascular Journal of Africa CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

1.30

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： The Cardiovascular Journal of Africa (CVJA) is an international peer-reviewed journal that keeps cardiologists up to date with advances in the diagnosis and treatment of cardiovascular disease. Topics covered include coronary disease, electrophysiology, valve disease, imaging techniques, congenital heart disease (fetal, paediatric and adult), heart failure, surgery, and basic science.