Podoplanin expression in lymph node metastases of head and neck cancer and cancer of unknown primary patients.

IF 2.3 4区 医学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Jan Philipp Kühn, Florian Bochen, Sandrina Körner, Bernhard Schick, Mathias Wagner, Sigrun Smola, Barbara Berkó-Göttel, Luc G T Morris, Jingming Wang, Alessandro Bozzato, Maximilian Linxweiler
{"title":"Podoplanin expression in lymph node metastases of head and neck cancer and cancer of unknown primary patients.","authors":"Jan Philipp Kühn,&nbsp;Florian Bochen,&nbsp;Sandrina Körner,&nbsp;Bernhard Schick,&nbsp;Mathias Wagner,&nbsp;Sigrun Smola,&nbsp;Barbara Berkó-Göttel,&nbsp;Luc G T Morris,&nbsp;Jingming Wang,&nbsp;Alessandro Bozzato,&nbsp;Maximilian Linxweiler","doi":"10.1177/03936155221105524","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Head and neck squamous cell carcinomas (HNSCCs) are cancers with generally poor prognosis. Outcomes have not improved in decades, with more than half of the patients presenting with lymph node metastases at the time of diagnosis. A unique subtype of HNSCC, cancer of unknown primary of the head and neck (HNCUP) is associated with a poor outcome. Increased expression of the D2-40 gene (podoplanin) has been described for several human malignancies and has been associated with increased metastatic potential of cancer cells.</p><p><strong>Methods: </strong>In order to examine the role of podoplanin in lymph node metastasis of HNSCC generally and HNCUP specifically, we evaluated the prognostic impact of podoplanin expression in HNSCC- (n = 68) and HNCUP-associated lymph node metastases (n = 30). The expression of podoplanin was analyzed by immunohistochemical staining of lymph node tissue samples and correlated with clinical and histopathological data.</p><p><strong>Results: </strong>We found a non-significant tendency towards a higher podoplanin expression in HNCUP compared to HNSCC lymph node metastases and a significant correlation between a high podoplanin expression and advanced node-stage classification. Podoplanin expression had no significant impact on overall survival for both groups and did not correlate with human papillomavirus tumor status.</p><p><strong>Conclusion: </strong>Taken together, our results suggest that upregulation of podoplanin may be associated with a stimulation of lymphatic metastasis in head and neck cancer.</p>","PeriodicalId":50334,"journal":{"name":"International Journal of Biological Markers","volume":null,"pages":null},"PeriodicalIF":2.3000,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Biological Markers","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/03936155221105524","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/7/25 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
引用次数: 1

Abstract

Introduction: Head and neck squamous cell carcinomas (HNSCCs) are cancers with generally poor prognosis. Outcomes have not improved in decades, with more than half of the patients presenting with lymph node metastases at the time of diagnosis. A unique subtype of HNSCC, cancer of unknown primary of the head and neck (HNCUP) is associated with a poor outcome. Increased expression of the D2-40 gene (podoplanin) has been described for several human malignancies and has been associated with increased metastatic potential of cancer cells.

Methods: In order to examine the role of podoplanin in lymph node metastasis of HNSCC generally and HNCUP specifically, we evaluated the prognostic impact of podoplanin expression in HNSCC- (n = 68) and HNCUP-associated lymph node metastases (n = 30). The expression of podoplanin was analyzed by immunohistochemical staining of lymph node tissue samples and correlated with clinical and histopathological data.

Results: We found a non-significant tendency towards a higher podoplanin expression in HNCUP compared to HNSCC lymph node metastases and a significant correlation between a high podoplanin expression and advanced node-stage classification. Podoplanin expression had no significant impact on overall survival for both groups and did not correlate with human papillomavirus tumor status.

Conclusion: Taken together, our results suggest that upregulation of podoplanin may be associated with a stimulation of lymphatic metastasis in head and neck cancer.

Podoplanin在头颈癌及未知原发癌患者淋巴结转移中的表达。
头颈部鳞状细胞癌(HNSCCs)是一种预后较差的癌症。几十年来,预后并没有改善,超过一半的患者在诊断时出现淋巴结转移。头颈部未知原发癌(HNCUP)是HNSCC的一种独特亚型,其预后较差。D2-40基因(podoplanin)的表达增加已被描述为几种人类恶性肿瘤,并与癌细胞转移潜力增加有关。方法:为了研究podoplanin在HNSCC和HNCUP淋巴结转移中的作用,我们评估了podoplanin在HNSCC- (n = 68)和HNCUP相关淋巴结转移(n = 30)中的表达对预后的影响。通过免疫组织化学染色分析淋巴结组织样本中podoplanin的表达,并与临床和组织病理学数据进行对比。结果:我们发现,与HNSCC淋巴结转移相比,HNCUP中podoplanin的高表达趋势不显著,而podoplanin的高表达与晚期淋巴结分期之间存在显著相关性。Podoplanin的表达对两组患者的总生存率没有显著影响,也与人乳头瘤病毒肿瘤状态无关。结论:综上所述,我们的研究结果表明,podoplanin的上调可能与头颈癌淋巴转移的刺激有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
International Journal of Biological Markers
International Journal of Biological Markers 医学-生物工程与应用微生物
CiteScore
4.10
自引率
0.00%
发文量
43
期刊介绍: IJBM is an international, online only, peer-reviewed Journal, which publishes original research and critical reviews primarily focused on cancer biomarkers. IJBM targets advanced topics regarding the application of biomarkers in oncology and is dedicated to solid tumors in adult subjects. The clinical scenarios of interests are screening and early diagnosis of cancer, prognostic assessment, prediction of the response to and monitoring of treatment.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信