Prevalence of skeletal-related events in hormone-naive prostate cancer in a low resource setting.

IF 0.8 Q3 MEDICINE, GENERAL & INTERNAL
Fredrick Obiefuna Ugwumba, Ikenna Ifeanyi Nnabugwu, Agharighom David Okoh, Kevin Ndubuisi Echetabu, Okechukwu Onwuasoigwe, Ekeoma Okey Nwosu
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Abstract

Background: Presentation with symptoms of advanced prostate cancer is prevalent in developing societies. The objective of this study was to determine the rate of and factors associated with skeletal-related events (SREs) at presentation with hormone-naïve prostate cancer.

Methods: Records of 331 consecutive prostate cancer patients from January 2009 to April 2018 were reviewed. The prevalence of SRE at the presentation was determined. In addition, the relationships between SRE and age of patient, duration of clinical features, serum total prostate-specific antigen (tPSA) and biopsy Gleason score (GS) at presentation were evaluated. Analyses were done with IBM SPSS® version 25.

Results: Mean age was 69.8 ± 8.0 years. While 43.8% of patients had lower urinary tract symptoms (LUTS) only, 51.4% had LUTS and other features of disease progression. Only 2.1% of the cases were confirmed from screen detection of elevated serum tPSA. SREs were observed in 11.8% at first presentations with hormone-naïve prostate cancer. Symptom duration (odds ratio [OR] 0.94; 95% confidence interval [CI] 0.90-0.99; P = 0.02), anaemia that could not be attributed to gross haematuria or external blood loss (OR 9.6; 95% CI 3.12-29.52; P < 0.001) and transrectal biopsy GS (OR 1.61; 95% CI 1.17-2.22; P = 0.003 ) were significantly associated with SREs at presentation with hormone-naïve prostate cancer.

Conclusions: Evidence exists that patients who present with SREs from more aggressive prostate cancers may have had more rapid symptom progression, but not a longer delay before presentation.

低资源环境下激素初始前列腺癌患者骨骼相关事件的患病率
背景:晚期前列腺癌的症状表现在发展中国家很普遍。本研究的目的是确定hormone-naïve前列腺癌患者骨骼相关事件(SREs)的发生率和相关因素。方法:回顾2009年1月至2018年4月连续331例前列腺癌患者的记录。确定了报告时SRE的患病率。此外,评估SRE与患者年龄、临床特征持续时间、首发时血清总前列腺特异性抗原(tPSA)和活检Gleason评分(GS)之间的关系。使用IBM SPSS®版本25进行分析。结果:平均年龄69.8±8.0岁。43.8%的患者仅有下尿路症状(LUTS), 51.4%的患者有下尿路症状和其他疾病进展特征。仅2.1%的病例通过筛查检测血清tPSA升高得到确诊。11.8%的患者首次出现hormone-naïve前列腺癌时出现SREs。症状持续时间(优势比[OR] 0.94;95%置信区间[CI] 0.90-0.99;P = 0.02),不能归因于肉眼血尿或外失血的贫血(or 9.6;95% ci 3.12-29.52;P < 0.001)和经直肠活检GS (OR 1.61;95% ci 1.17-2.22;P = 0.003)与hormone-naïve前列腺癌患者的SREs显著相关。结论:有证据表明,侵袭性更强的前列腺癌患者出现SREs的症状进展可能更快,但在出现症状之前的延迟时间不会更长。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Nigerian Postgraduate Medical Journal
Nigerian Postgraduate Medical Journal MEDICINE, GENERAL & INTERNAL-
CiteScore
1.90
自引率
0.00%
发文量
52
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