Epigenetic Control of Vascular Smooth Muscle Cell Function in Atherosclerosis: A Role for DNA Methylation.

IF 2.6 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

DNA and cell biology Pub Date : 2022-09-01 Epub Date: 2022-07-27 DOI:10.1089/dna.2022.0278

Yanjun Chen, Lingli Liang, Chunyan Wu, Zitong Cao, Linzhen Xia, Jun Meng, Zuo Wang

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引用次数: 1

Abstract

Atherosclerosis is a complex vascular inflammatory disease in which multiple cell types are involved, including vascular smooth muscle cells (VSMCs). In response to vascular injury and inflammatory stimuli, VSMCs undergo a "phenotypic switching" characterized by extracellular matrix secretion, loss of contractility, and abnormal proliferation and migration, which play a key role in the progression of atherosclerosis. DNA methylation modification is an important epigenetic mechanism that plays an important role in atherosclerosis. Studies investigating abnormal DNA methylation in patients with atherosclerosis have determined a specific DNA methylation profile, and proposed multiple pathways and genes involved in the etiopathogenesis of atherosclerosis. Recent studies have also revealed that DNA methylation modification controls VSMC function by regulating gene expression involved in atherosclerosis. In this review, we summarize the recent advances regarding the epigenetic control of VSMC function by DNA methylation in atherosclerosis and provide insights into the development of VSMC-centered therapeutic strategies.

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动脉粥样硬化中血管平滑肌细胞功能的表观遗传控制:DNA甲基化的作用。

动脉粥样硬化是一种复杂的血管炎性疾病，涉及多种细胞类型，包括血管平滑肌细胞(VSMCs)。在血管损伤和炎症刺激下，VSMCs发生以细胞外基质分泌、收缩性丧失、异常增殖和迁移为特征的“表型转换”，在动脉粥样硬化的进展中起关键作用。DNA甲基化修饰是一种重要的表观遗传机制，在动脉粥样硬化中起重要作用。对动脉粥样硬化患者异常DNA甲基化的研究已经确定了特定的DNA甲基化谱，并提出了参与动脉粥样硬化发病的多种途径和基因。最近的研究也表明DNA甲基化修饰通过调节与动脉粥样硬化相关的基因表达来控制VSMC功能。本文综述了动脉粥样硬化中DNA甲基化对VSMC功能的表观遗传控制的最新进展，并对以VSMC为中心的治疗策略的发展提出了见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

DNA and cell biology 生物-生化与分子生物学

CiteScore

6.60

自引率

0.00%

发文量

审稿时长

1.5 months

期刊介绍： DNA and Cell Biology delivers authoritative, peer-reviewed research on all aspects of molecular and cellular biology, with a unique focus on combining mechanistic and clinical studies to drive the field forward. DNA and Cell Biology coverage includes: Gene Structure, Function, and Regulation Gene regulation Molecular mechanisms of cell activation Mechanisms of transcriptional, translational, or epigenetic control of gene expression Molecular Medicine Molecular pathogenesis Genetic approaches to cancer and autoimmune diseases Translational studies in cell and molecular biology Cellular Organelles Autophagy Apoptosis P bodies Peroxisosomes Protein Biosynthesis and Degradation Regulation of protein synthesis Post-translational modifications Control of degradation Cell-Autonomous Inflammation and Host Cell Response to Infection Responses to cytokines and other physiological mediators Evasive pathways of pathogens.