Effect of long-acting growth hormone treatment on endogenous growth hormone secretion in prepubertal patients with idiopathic short stature: A preliminary study

IF 1.6 4区 医学 Q4 CELL BIOLOGY
Han Saem Choi, Ahreum Kwon, Junghwan Suh, Kyungchul Song, Hyun Wook Chae, Ho-Seong Kim
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引用次数: 1

Abstract

Long-acting growth hormone (LAGH) is emerging to be a new preparation for treatment of short stature. We aimed to determine whether 12-month treatment with LAGH in patients with idiopathic short stature has an effect on the nocturnal endogenous growth hormone (GH) secretion and metabolic consequences and efficacy. Participants included 10 GH-naïve prepubertal children with idiopathic short stature (ISS). One patient was withdrawn due to own decline during study. Participants were randomized on a 1:1 ratio to receive either a daily GH (0.37 mg/kg/week) or once-weekly LAGH (0.7 mg/kg/week) over a 12-month period. Nocturnal endogenous GH secretory profiles obtained from 12-h blood samplings at 30-min interval were assessed at baseline and 2 weeks after the completion of GH treatment. Post-treatment changes in height velocity, height standard deviation score (SDS), metabolic parameters, and adverse events were measured. A total of 4 patients received LAGH, and 5 patients received daily GH. Nocturnal endogenous GH secretory profiles, such as mean serum GH concentrations, frequency, amplitude, interpulse interval of spontaneous GH secretory bursts, and mass of GH released per secretory burst were similar at baseline and after 12-month treatment in both groups. The efficacy and safety after LAGH treatment for 12 months were similar to those of daily GH. In conclusions, these findings indicated that LAGH does not suppress endogenous GH secretion, and can be used for treatment of non-GH deficient short stature with similar efficacy and safety compared to daily GH. These may contribute to define and develop treatment and follow-up protocols for LAGH use in ISS patients.

长效生长激素治疗对青春期前特发性身材矮小患者内源性生长激素分泌影响的初步研究
长效生长激素(Long-acting growth hormone, LAGH)是治疗身材矮小的新制剂。我们的目的是确定特发性身材矮小患者12个月的LAGH治疗是否对夜间内源性生长激素(GH)分泌和代谢后果和疗效有影响。参与者包括10名GH-naïve特发性身材矮小(ISS)的青春期前儿童。1例患者在研究过程中因自身衰退退出。在12个月的时间里,参与者按1:1的比例随机接受每日生长激素(0.37 mg/kg/周)或每周一次LAGH (0.7 mg/kg/周)。在基线和GH治疗完成后2周,对间隔30分钟的12小时血样中获得的夜间内源性GH分泌谱进行评估。测量治疗后身高速度、身高标准差评分(SDS)、代谢参数和不良事件的变化。4例患者接受LAGH治疗,5例患者每日接受GH治疗。两组在基线和治疗12个月后,夜间内源性生长激素分泌谱,如平均血清生长激素浓度、频率、幅度、自发生长激素分泌爆发的脉间间隔和每次分泌爆发释放的生长激素质量相似。LAGH治疗12个月后的疗效和安全性与每日GH相似。综上所述,这些发现表明LAGH不抑制内源性GH分泌,与每日GH相比,LAGH可用于治疗非GH缺乏的矮小身材,其疗效和安全性相似。这些可能有助于确定和制定ISS患者使用LAGH的治疗和随访方案。
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来源期刊
Growth Hormone & Igf Research
Growth Hormone & Igf Research 医学-内分泌学与代谢
CiteScore
3.30
自引率
0.00%
发文量
38
审稿时长
57 days
期刊介绍: Growth Hormone & IGF Research is a forum for research on the regulation of growth and metabolism in humans, animals, tissues and cells. It publishes articles on all aspects of growth-promoting and growth-inhibiting hormones and factors, with particular emphasis on insulin-like growth factors (IGFs) and growth hormone. This reflects the increasing importance of growth hormone and IGFs in clinical medicine and in the treatment of diseases.
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