Telomerase Activity in Androgenetic Rainbow Trout with Growth Deficiency and in Normally Developed Individuals.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2022-08-01 Epub Date: 2022-07-22 DOI:10.1089/zeb.2022.0012

Ligia Panasiak, Marcin Kuciński, Agata Błaszczyk, Konrad Ocalewicz

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引用次数: 1

Abstract

Role of telomerase in specimens with retarded growth (dwarfs) has not been thoroughly examined to date. Considering that some of the fish species show correlation between somatic growth and activity of telomerase, it has been tempting to assume that pattern of telomerase activity in specimens with retarded growth and these with normal growth rate may vary. In the present research, telomerase activity has been examined in liver, skin, and muscles in the androgenetic rainbow trout (Oncorhynchus mykiss) with growth deficiency and their normally developed siblings. Among the examined organs, the liver showed the highest telomerase activity in all studied fish, what may be linked to the enormous regeneration capacity of the liver tissue. Although dwarf specimens examined here displayed significantly lower body size and weight they did not exhibit any significant differences in the telomerase activity measured in liver and muscle when compared to the rainbow trout without growth deficiency. In turn, telomerase activity in skin was significantly upregulated in the normally developed androgenotes. The present study indicates that dwarfism in the androgenetic rainbow trout is neither associated with ceased telomerase activity nor its decrease throughout the ontogenetic development.

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生长缺陷和正常发育个体雄激素性虹鳟的端粒酶活性。

端粒酶在生长迟缓(侏儒)标本中的作用至今尚未得到彻底的研究。考虑到一些鱼类的体细胞生长与端粒酶活性之间存在相关性，人们很容易认为，生长迟缓的鱼类和生长正常的鱼类的端粒酶活性模式可能存在差异。在目前的研究中，端粒酶活性已被检测在肝脏，皮肤和肌肉的雄性发育虹鳟鱼(Oncorhynchus mykiss)生长缺陷及其正常发育的兄弟姐妹。在被检查的器官中，肝脏在所有被研究的鱼类中显示出最高的端粒酶活性，这可能与肝脏组织的巨大再生能力有关。虽然这里检查的侏儒标本显示出明显较低的体型和体重，但与没有生长缺陷的虹鳟相比，它们在肝脏和肌肉中测量的端粒酶活性没有任何显着差异。反过来，皮肤端粒酶活性在正常发育的雄激素中显着上调。目前的研究表明，雄性发育虹鳟鱼的侏儒症与端粒酶活性的停止或其在整个个体发育过程中的降低无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.