[A Prognostic Nomogram Based on Response to Bortezomib and BTK Expression for Treatment-Experienced Multiple Myeloma Patients].

Zhongguo shi yan xue ye xue za zhi Pub Date : 2022-08-01 DOI:10.19746/j.cnki.issn.1009-2137.2022.04.025

Hui-Ling Chen, Cheng-Cheng Ma, Ye Chai, Peng-Yun Zeng, Chong-Yang Wu, Ling-Ling Yue, Ti-Yun Han, De-Kui Zhang

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Abstract

Objective: To establish a prognostic nomogram based on response to bortezomib and BTK expression for treatment-experienced multiple myeloma patients.

Methods: The Oncomine database was utilized to determine BTK expression, sex, age, albumin, Mayo index, response to bortezomib treatment, follow-up time and survival status in multiple myeloma(MM) patients. Cut-off point for BTK expression was calculated using R software. Univariate and multivariate analyses by Cox proportional hazards regression were then performed. Significant prognostic factors were combined to build a nomogram. The discrimination ability and predictive accuracy of the nomogram were evaluated using the index of concordance (C-index) and calibration curves.

Results: Multivariate analysis showed that response to bortezomib, BTK expression and sex were independent risk factors for prognosis. The C-index value of the nomogram made according to the independent risk factors was 0.729 (95%CI, 0.642-0.8164). The calibration curves showed good consistency between predicted and actual survivals for 1-year and 2-year overall survival.

Conclusion: The proposed nomogram is accurate in predicting the prognosis of patients with MM.

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[基于治疗经验的多发性骨髓瘤患者对硼替佐米和BTK表达反应的预后Nomogram]。

目的:建立基于治疗经验的多发性骨髓瘤患者对硼替佐米和BTK表达反应的预后图。方法:利用Oncomine数据库检测多发性骨髓瘤(MM)患者BTK表达、性别、年龄、白蛋白、Mayo指数、硼替佐米治疗反应、随访时间及生存状况。用R软件计算BTK表达的截断点。采用Cox比例风险回归进行单因素和多因素分析。将重要的预后因素结合起来建立nomogram。采用一致性指数(C-index)和标定曲线评价nomogram鉴别能力和预测精度。结果:多因素分析显示，对硼替佐米的反应、BTK表达和性别是影响预后的独立危险因素。根据独立危险因素制作的nomogram C-index值为0.729 (95%CI, 0.642 ~ 0.8164)。校准曲线显示，1年和2年总生存期的预测生存期与实际生存期具有良好的一致性。结论:所建立的影像学图能准确预测MM患者的预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Zhongguo shi yan xue ye xue za zhi

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