The Eyes Have It-for Idiopathic Pulmonary Fibrosis: a Preliminary Observation.

IF 2.3 Q2 RESPIRATORY SYSTEM

Pulmonary Therapy Pub Date : 2022-09-01 Epub Date: 2022-08-04 DOI:10.1007/s41030-022-00198-5

Roy A Pleasants, Armando D Bedoya, Joel M Boggan, Karen Welty-Wolf, Robert M Tighe

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引用次数: 1

Abstract

Introduction: The disease origins of idiopathic pulmonary fibrosis (IPF), which occurs at higher rates in certain races/ethnicities, are not understood. The highest rates occur in white persons of European descent, particularly those with light skin, who are also susceptible to lysosomal organelle dysfunction of the skin leading to fibroproliferative disease . We had observed clinically that the vast majority of patients with IPF had light-colored eyes, suggesting a phenotypic characteristic.

Methods: We pursued this observation through a research database from the USA Veterans Administration, a population that has a high occurrence of IPF due to predominance of elderly male smokers. Using this medical records database, which included facial photos, we compared the frequency of light (blue, green, hazel) and dark (light brown, brown) eyes among white patients diagnosed with IPF compared with a control group of lung granuloma only (no other radiologic evidence of interstitial lung disease).

Results: Light eye color was significantly more prevalent in patients with IPF than in the control group with lung granuloma [114/147 (77.6%) versus 129/263 (49.0%], p < 0.001), indicating that light-colored eyes are a phenotype associated with IPF .

Conclusion: We provide evidence that light eye color is predominant among white persons with IPF.

Abstract Image

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特发性肺纤维化:初步观察。

特发性肺纤维化(IPF)在某些种族/民族中发病率较高，其疾病起源尚不清楚。发病率最高的是欧洲血统的白人，特别是浅色皮肤的白人，他们也容易受到皮肤溶酶体细胞器功能障碍的影响，从而导致纤维增生性疾病。我们在临床上观察到，绝大多数IPF患者的眼睛颜色都是浅色的，这表明了一种表型特征。方法:我们通过美国退伍军人管理局的研究数据库进行了这一观察，这是一个由于老年男性吸烟者占主导地位而导致IPF发生率高的人群。使用包括面部照片在内的医疗记录数据库，我们比较了诊断为IPF的白人患者中浅色(蓝色、绿色、淡褐色)和深色(浅棕色、棕色)眼睛的频率，并与只有肺肉芽肿的对照组(没有其他肺间质性疾病的放射学证据)进行了比较。结果:浅眼色在IPF患者中明显高于肺肉芽肿对照组[114/147(77.6%)比129/263(49.0%)]。结论:我们提供的证据表明浅眼色在白人IPF患者中占主导地位。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pulmonary Therapy Medicine-Pulmonary and Respiratory Medicine

CiteScore

5.20

自引率

3.30%

发文量

审稿时长

6 weeks

期刊介绍： Aims and Scope Pulmonary Therapy is an international, open access, peer-reviewed (single-blind), and rapid publication journal. The scope of the journal is broad and will consider all scientifically sound research from pre-clinical, clinical (all phases), observational, real-world, and health outcomes research around the use of pulmonary therapies, devices, and surgical techniques. Areas of focus include, but are not limited to: asthma; chronic obstructive pulmonary disease; idiopathic pulmonary fibrosis; pulmonary hypertension; cystic fibrosis; lung cancer; respiratory tract disorders; allergic rhinitis and other respiratory allergies; influenza, pneumococcal infection, respiratory syncytial virus and other respiratory infections; and inhalers and other device therapies. The journal is of interest to a broad audience of pharmaceutical and healthcare professionals and publishes original research, reviews, case reports/series, trial protocols and short communications such as commentaries and editorials. Pulmonary Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of quality research, which may be considered of insufficient interest by other journals. Rapid Publication The journal’s publication timelines aim for a rapid peer review of 2 weeks. If an article is accepted it will be published 3–4 weeks from acceptance. The rapid timelines are achieved through the combination of a dedicated in-house editorial team, who manage article workflow, and an extensive Editorial and Advisory Board who assist with peer review. This allows the journal to support the rapid dissemination of research, whilst still providing robust peer review. Combined with the journal’s open access model this allows for the rapid, efficient communication of the latest research and reviews, fostering the advancement of pulmonary therapies. Open Access All articles published by Pulmonary Therapy are open access. Personal Service The journal’s dedicated in-house editorial team offer a personal “concierge service” meaning authors will always have an editorial contact able to update them on the status of their manuscript. The editorial team check all manuscripts to ensure that articles conform to the most recent COPE, GPP and ICMJE publishing guidelines. This supports the publication of ethically sound and transparent research. 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