The multifaceted actions of the lncRNA H19 in cardiovascular biology and diseases.

Clinical Science (London, England : 1979) Pub Date : 2022-08-12 DOI:10.1042/CS20210994

Denise Busscher, Reinier A Boon, Rio P Juni

{"title":"The multifaceted actions of the lncRNA H19 in cardiovascular biology and diseases.","authors":"Denise Busscher, Reinier A Boon, Rio P Juni","doi":"10.1042/CS20210994","DOIUrl":null,"url":null,"abstract":"<p><p>Cardiovascular diseases are the leading cause of death and debility worldwide. Various molecular mechanisms have been studied to better understand the development and progression of cardiovascular pathologies with hope to eradicate these diseases. With the advancement of the sequencing technology, it is revealed that the majority of our genome is non-coding. A growing body of literature demonstrates the critical role of long non-coding RNAs (lncRNAs) as epigenetic regulators of gene expression. LncRNAs can regulate cellular biological processes through various distinct molecular mechanisms. The abundance of lncRNAs in the cardiovascular system indicates their significance in cardiovascular physiology and pathology. LncRNA H19, in particular, is a highly evolutionarily conserved lncRNA that is enriched in cardiac and vascular tissue, underlining its importance in maintaining homeostasis of the cardiovascular system. In this review, we discuss the versatile function of H19 in various types of cardiovascular diseases. We highlight the current literature on H19 in the cardiovascular system and demonstrate how dysregulation of H19 induces the development of cardiovascular pathophysiology.</p>","PeriodicalId":519494,"journal":{"name":"Clinical Science (London, England : 1979)","volume":" ","pages":"1157-1178"},"PeriodicalIF":0.0000,"publicationDate":"2022-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9366862/pdf/","citationCount":"10","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Science (London, England : 1979)","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1042/CS20210994","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 10

Abstract

Cardiovascular diseases are the leading cause of death and debility worldwide. Various molecular mechanisms have been studied to better understand the development and progression of cardiovascular pathologies with hope to eradicate these diseases. With the advancement of the sequencing technology, it is revealed that the majority of our genome is non-coding. A growing body of literature demonstrates the critical role of long non-coding RNAs (lncRNAs) as epigenetic regulators of gene expression. LncRNAs can regulate cellular biological processes through various distinct molecular mechanisms. The abundance of lncRNAs in the cardiovascular system indicates their significance in cardiovascular physiology and pathology. LncRNA H19, in particular, is a highly evolutionarily conserved lncRNA that is enriched in cardiac and vascular tissue, underlining its importance in maintaining homeostasis of the cardiovascular system. In this review, we discuss the versatile function of H19 in various types of cardiovascular diseases. We highlight the current literature on H19 in the cardiovascular system and demonstrate how dysregulation of H19 induces the development of cardiovascular pathophysiology.

Abstract Image

查看原文本刊更多论文

lncRNA H19在心血管生物学和疾病中的多方面作用。

心血管疾病是世界范围内导致死亡和衰弱的主要原因。为了更好地了解心血管疾病的发生和发展，并希望根除这些疾病，人们研究了各种分子机制。随着测序技术的进步，我们的基因组大部分是非编码的。越来越多的文献证明了长链非编码rna (lncRNAs)作为基因表达的表观遗传调控因子的关键作用。LncRNAs可以通过多种不同的分子机制调控细胞生物学过程。lncrna在心血管系统中的丰度表明其在心血管生理和病理中的重要意义。特别是LncRNA H19，是一种高度进化保守的LncRNA，在心脏和血管组织中富集，强调了其在维持心血管系统稳态中的重要性。在这篇综述中，我们讨论了H19在各种心血管疾病中的多种功能。我们重点介绍了目前关于H19在心血管系统中的作用的文献，并展示了H19的失调如何诱导心血管病理生理的发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Clinical Science (London, England : 1979)

自引率

0.00%

发文量