The Role of Alternative Splicing in Cancer: Regulatory Mechanism, Therapeutic Strategy, and Bioinformatics Application.

IF 2.6 4区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
DNA and cell biology Pub Date : 2022-09-01 Epub Date: 2022-08-10 DOI:10.1089/dna.2022.0322
Yao-Jie Pan, Bo-Wen Liu, Dong-Sheng Pei
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引用次数: 0

Abstract

[Formula: see text] Alternative splicing (AS) can generate distinct transcripts and subsequent isoforms that play differential functions from the same pre-mRNA. Recently, increasing numbers of studies have emerged, unmasking the association between AS and cancer. In this review, we arranged AS events that are closely related to cancer progression and presented promising treatments based on AS for cancer therapy. Obtaining proliferative capacity, acquiring invasive properties, gaining angiogenic features, shifting metabolic ability, and getting immune escape inclination are all splicing events involved in biological processes. Spliceosome-targeted and antisense oligonucleotide technologies are two novel strategies that are hopeful in tumor therapy. In addition, bioinformatics applications based on AS were summarized for better prediction and elucidation of regulatory routines mingled in. Together, we aimed to provide a better understanding of complicated AS events associated with cancer biology and reveal AS a promising target of cancer treatment in the future.

选择性剪接在癌症中的作用:调控机制、治疗策略和生物信息学应用。
【公式:见正文】选择性剪接(AS)可以产生不同的转录本和随后的同工异构体,这些同工异构体与相同的前mrna具有不同的功能。最近,越来越多的研究揭示了AS和癌症之间的联系。在这篇综述中,我们整理了与癌症进展密切相关的AS事件,并提出了基于AS治疗癌症的有希望的治疗方法。获得增殖能力、获得侵袭性、获得血管生成特征、改变代谢能力以及获得免疫逃逸倾向都是剪接过程中涉及的事件。剪接体靶向技术和反义寡核苷酸技术是两种有希望用于肿瘤治疗的新策略。此外,综述了基于AS的生物信息学应用,以期更好地预测和阐明混合在其中的调控程序。总之,我们旨在更好地了解与癌症生物学相关的复杂AS事件,并揭示AS在未来癌症治疗中的一个有希望的靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
DNA and cell biology
DNA and cell biology 生物-生化与分子生物学
CiteScore
6.60
自引率
0.00%
发文量
93
审稿时长
1.5 months
期刊介绍: DNA and Cell Biology delivers authoritative, peer-reviewed research on all aspects of molecular and cellular biology, with a unique focus on combining mechanistic and clinical studies to drive the field forward. DNA and Cell Biology coverage includes: Gene Structure, Function, and Regulation Gene regulation Molecular mechanisms of cell activation Mechanisms of transcriptional, translational, or epigenetic control of gene expression Molecular Medicine Molecular pathogenesis Genetic approaches to cancer and autoimmune diseases Translational studies in cell and molecular biology Cellular Organelles Autophagy Apoptosis P bodies Peroxisosomes Protein Biosynthesis and Degradation Regulation of protein synthesis Post-translational modifications Control of degradation Cell-Autonomous Inflammation and Host Cell Response to Infection Responses to cytokines and other physiological mediators Evasive pathways of pathogens.
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