Important Role of Estrogen in Distinguishing Depression and Schizophrenia and Prognostic Judgment of MECT.

IF 0.6 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Neuro endocrinology letters Pub Date : 2022-04-01

Xi-Long Jin, Bao-Hua Song, Xu-Dong Zhao, Min Feng, Gang Song, Guangbiao Huang

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引用次数: 0

Abstract

Objectives: This study aimed to investigate the role of estrogen in the differential diagnosis of depression and schizophrenia and its relationship with the curative effects, adverse events.

Methods: From 2017 to 2019, patients with depression or schizophrenia treated with modern electroconvulsive therapy (MECT) were studied retrospectively. Their serum estrogen levels, Hamilton Depression Scale, and Brief Psychiatric Rating Scale scores were collected. Differences in the estrogen levels between patients with depression and schizophrenia before and after treatment and the correlation of the estrogen level with curative effect and adverse events was evaluated. In total, 67 patients with depression and 61 with schizophrenia were included.

Results: There were no significant differences in the baseline characteristics, except the estrogen level (p < 0.001). Serum estrogen levels increased in both groups after MECT (117 vs. 141 pmol/L, p < 0.001; 42 vs. 46 pmol/L, respectively; p < 0.001), and higher estrogen levels were positively correlated with better outcomes (p < 0.001).

Conclusion: Post-MECT estrogen levels were not associated with the incidence rate of adverse events of MECT. Estrogen plays a promising role in distinguishing depression and schizophrenia and evaluating the therapeutic efficacy of MECT.

本刊更多论文

雌激素在抑郁症与精神分裂症的鉴别及MECT预后判断中的重要作用。

目的:探讨雌激素在抑郁症和精神分裂症鉴别诊断中的作用及其与疗效、不良事件的关系。方法:对2017 - 2019年接受现代电休克治疗的抑郁症或精神分裂症患者进行回顾性分析。收集他们的血清雌激素水平、汉密尔顿抑郁量表和简短精神病学评定量表得分。观察抑郁症和精神分裂症患者治疗前后雌激素水平的差异，以及雌激素水平与疗效和不良事件的相关性。总共包括67名抑郁症患者和61名精神分裂症患者。结果:除雌激素水平外，两组基线特征无显著差异(p < 0.001)。MECT后两组血清雌激素水平均升高(117比141 pmol/L, p < 0.001;分别为42和46 pmol/L;P < 0.001)，较高的雌激素水平与较好的预后呈正相关(P < 0.001)。结论:MECT后雌激素水平与MECT不良事件发生率无相关性。雌激素在区分抑郁症和精神分裂症以及评价MECT治疗效果方面具有重要意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuro endocrinology letters 医学-内分泌学与代谢

CiteScore

1.00

自引率

14.30%

发文量

审稿时长

6 months

期刊介绍： Neuroendocrinology Letters is an international, peer-reviewed interdisciplinary journal covering the fields of Neuroendocrinology, Neuroscience, Neurophysiology, Neuropsychopharmacology, Psychoneuroimmunology, Reproductive Medicine, Chronobiology, Human Ethology and related fields for RAPID publication of Original Papers, Review Articles, State-of-the-art, Clinical Reports and other contributions from all the fields covered by Neuroendocrinology Letters. Papers from both basic research (methodology, molecular and cellular biology, anatomy, histology, biology, embryology, teratology, normal and pathological physiology, biophysics, pharmacology, pathology and experimental pathology, biochemistry, neurochemistry, enzymology, chronobiology, receptor studies, endocrinology, immunology and neuroimmunology, animal physiology, animal breeding and ethology, human ethology, psychology and others) and from clinical research (neurology, psychiatry and child psychiatry, obstetrics and gynecology, pediatrics, endocrinology, immunology, cardiovascular studies, internal medicine, oncology and others) will be considered. The Journal publishes Original papers and Review Articles. Brief reports, Special Communications, proved they are based on adequate experimental evidence, Clinical Studies, Case Reports, Commentaries, Discussions, Letters to the Editor (correspondence column), Book Reviews, Congress Reports and other categories of articles (philosophy, art, social issues, medical and health policies, biomedical history, etc.) will be taken under consideration.