Valvular heart diseases in immigrants and Swedish-born individuals: a national cohort study.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2022-12-01 DOI:10.1080/14017431.2022.2095014

Per Wändell, Xinjun Li, Axel C Carlsson, Jan Sundquist, Kristina Sundquist

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Abstract

Objectives. The aim of this study was to analyse the risk of valvular heart diseases among foreign-born individuals in Sweden. Design. This was a nationwide study of individuals aged 18 years of age and older (N = 6,118,649; 2,970,055 men and 3,148,594 women). Valvular heart diseases were defined as at least one registered diagnosis in the National Patient Register between 1 January 1998 and 31 December 2012. Cox regression analysis was used to estimate hazard ratios (HR) with 99% confidence intervals (CI) of incident valvular heart diseases in foreign-born individuals compared to Swedish natives. The Cox regression models were adjusted for age, co-morbidities, and sociodemographic factors. Sub-categories were chronic rheumatic valvular heart diseases and non-rheumatic valvular heart diseases. Results. There were 64,979 male cases and 59,075 female cases. Fully adjusted HRs (99% CI) were among immigrant men 0.86 (0.82-0.89) and immigrant women 0.96 (0.92-1.00). For chronic rheumatic valvular disease among immigrant men and women, the HRs were 1.62 (1.37-1.92) and 1.75 (1.52-2.00), respectively, and, for non-rheumatic valvular disease among immigrant men 0.83 (0.80-0.87) and immigrant women 0.92 (0.88-0.96). Increased risks for chronic rheumatic valvular disease were found among men from Southern, Eastern and Central Europe, Africa and Asia and among women from Western, Eastern and Central Europe and Africa, Latin America and Asia. Conclusions. We observed lower risks in general of valvular heart disease, but higher risks of chronic rheumatic valvular heart disease in immigrants, which is important in the clinical situation.

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移民和瑞典出生个体的瓣膜性心脏病:一项全国性队列研究。

目标。这项研究的目的是分析在瑞典出生的外国人患瓣膜性心脏病的风险。设计。这是一项针对18岁及以上个体的全国性研究(N = 6,118,649;2970,055名男性和3,148,594名女性)。在1998年1月1日至2012年12月31日期间，在国家患者登记册中至少有一种登记诊断为瓣膜性心脏病。Cox回归分析用于估计外国出生个体与瑞典本地人相比发生瓣膜性心脏病的99%可信区间(CI)的风险比(HR)。Cox回归模型根据年龄、合并症和社会人口因素进行了调整。分慢性风湿性心脏瓣膜病和非风湿性心脏瓣膜病。结果。男性64,979例，女性59,075例。男性移民的完全调整hr (99% CI)为0.86(0.82-0.89)，女性移民为0.96(0.92-1.00)。对于慢性风湿性瓣膜病，移民男性和女性的hr分别为1.62(1.37-1.92)和1.75(1.52-2.00)，对于非风湿性瓣膜病，移民男性为0.83(0.80-0.87)，移民女性为0.92(0.88-0.96)。南欧、东欧和中欧、非洲和亚洲的男性以及西欧、东欧和中欧、非洲、拉丁美洲和亚洲的女性患慢性风湿性瓣膜病的风险增加。结论。我们观察到移民患心脏瓣膜病的风险总体较低，但患慢性风湿性心脏瓣膜病的风险较高，这在临床情况中具有重要意义。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.