Prolactin response to growth hormone stimulation tests

IF 1.6 4区医学 Q4 CELL BIOLOGY

Growth Hormone & Igf Research Pub Date : 2022-08-01 DOI:10.1016/j.ghir.2022.101483

Avivah Silbergeld , Chen Barazani , Zvi Laron

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引用次数: 0

Abstract

Background

Despite many similarities between the structure, receptors, proliferative and growth promoting actions, the relationship between Prolactin (PRL) and Growth Hormone (GH) in clinical conditions has received little attention.

Objective

To determine the PRL response to GH stimulation tests.

Subjects

Prepubertal and early pubertal boys (n = 581) and girls (n = 502) with idiopathic, non-syndromatic short stature.

Design

Data was retrieved from the computerized records of the Endocrine Laboratory, Schneider Children's Medical Center. Peak GH and PRL levels during GH stimulation tests with glucagon (Gluc), Clonidine (Clon) and Clonidine with arginine (Clon+Arg), were compared. Both PRL and GH were determined by radioimmunoassay.

Results

Whereas Gluc stimulated both GH and PRL to similar levels, Clon alone or combined with Arg suppressed the PRL secretion (p < 0.0001). It is also evident that in both boys and girls Clon alone and Clon±Arg are superior to Gluc in GH stimulation. The higher GH levels during Clon+Arg than with Clon alone are attributed to the pubertal stage.

Conclusion

This study provides further information on the Prolactin-Growth hormone relationship in children.

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催乳素对生长激素刺激试验的反应

尽管泌乳素(Prolactin, PRL)与生长激素(growth Hormone, GH)在结构、受体、促增殖和促生长作用等方面有许多相似之处，但它们在临床中的关系却很少受到关注。目的探讨肾上腺素对激素刺激试验的反应。研究对象特发性、非综合征性身材矮小的青春期和青春期早期男孩(n = 581)和女孩(n = 502)。设计数据来源于施耐德儿童医学中心内分泌实验室的计算机记录。比较用胰高血糖素(Gluc)、可乐定(Clon)和可乐定加精氨酸(Clon+Arg)进行GH刺激试验时GH和PRL的峰值水平。放射免疫法测定PRL和GH。结果葡萄糖对生长激素和PRL的刺激均达到相似水平，而克隆单用或与精氨酸联用均抑制PRL的分泌(p <0.0001)。在男孩和女孩中，Clon单独和Clon±Arg对生长激素的刺激也明显优于Gluc。克隆+精氨酸期间的生长激素水平高于克隆单独使用时的生长激素水平归因于青春期。结论本研究为儿童催乳素与生长激素的关系提供了进一步的信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Growth Hormone & Igf Research 医学-内分泌学与代谢

CiteScore

3.30

自引率

0.00%

发文量

审稿时长

57 days

期刊介绍： Growth Hormone & IGF Research is a forum for research on the regulation of growth and metabolism in humans, animals, tissues and cells. It publishes articles on all aspects of growth-promoting and growth-inhibiting hormones and factors, with particular emphasis on insulin-like growth factors (IGFs) and growth hormone. This reflects the increasing importance of growth hormone and IGFs in clinical medicine and in the treatment of diseases.