Endometrial compaction after human chorionic gonadotrophin administration reduces ectopic pregnancy rate following fresh embryo transfer in vitro fertilization/intracytoplasmic sperm injection cycles in patients with non-thin endometrium: a retrospective cohort study.

Qiuyuan Li, Ahui Liu, Haofei Shen, Xuehong Zhang
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引用次数: 3

Abstract

Background: This study aims to study whether the change of endometrial thickness between the day of human chorionic gonadotrophin (HCG) administration and the day of embryo transfer (ET) has any effect on ectopic pregnancy (EP) rate following fresh in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycles.

Methods: This study retrospectively analyzed 3134 patients who underwent fresh IVF/ICSI ET, including 3022 intrauterine, 112 ectopic cycles. Multiple logistic regression analysis and stratified analysis were used to study the effect of endometrial compaction after HCG administration on EP in patients with non-thin endometrium after adjusting for confounding factors.

Results: After adjusting for confounders, multiple logistic regression analysis found that the risk of EP in the compaction group was significantly lower than that in the non-compaction group (OR = 0.49; 95% CI: 0.31-0.78; P = 0.0023). The results of the stratified analysis demonstrated the EP rate in patients with an endometrial thickness ≥ 8 mm on the day of ET; the compaction group significantly reduced the incidence of EP (OR = 0.49; 95% CI: 0.31-0.79; P = 0.0036). In patients with an endometrial thickness ≥ 8 mm on the day of ET, the incidence of EP had no statistical significance in two group (OR = 1.02; 95% CI: 0.18-5.88; P = 9790).

Conclusion(s): In patients with non-thin endometrium, endometrial thickness compaction from the day of HCG to the ET day reduced the risk of EP significantly.

Abstract Image

Abstract Image

人绒毛膜促性腺激素给药后子宫内膜压实降低非薄子宫内膜患者新鲜胚胎移植体外受精/胞浆内单精子注射周期后异位妊娠率:一项回顾性队列研究
背景:本研究旨在研究新鲜体外受精/卵胞浆内单精子注射(IVF/ICSI)周期后,人绒毛膜促性腺激素(HCG)给药日至胚胎移植(ET)日子宫内膜厚度的变化是否对异位妊娠(EP)率有影响。方法:本研究回顾性分析3134例新鲜IVF/ICSI ET患者,包括3022例宫内周期,112例异位周期。采用多元logistic回归分析和分层分析,在调整混杂因素后,研究非薄子宫内膜患者给予HCG后子宫内膜压实对EP的影响。结果:经混杂因素调整后,多元logistic回归分析发现压实组EP发生风险显著低于非压实组(OR = 0.49;95% ci: 0.31-0.78;p = 0.0023)。分层分析结果显示,子宫内膜厚度≥8 mm的患者在ET当天的EP率较高;压实组显著降低EP发生率(OR = 0.49;95% ci: 0.31-0.79;p = 0.0036)。在ET当天子宫内膜厚度≥8 mm的患者中,两组EP发生率比较,差异无统计学意义(OR = 1.02;95% ci: 0.18-5.88;结论:在非薄子宫内膜患者中,从HCG当天到ET当天的子宫内膜厚度压实可显著降低EP的风险。
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