Interaction of SARS-CoV-2 With RAS / ACE2 in the Female Reproductive System.

Journal of Family and Reproductive Health Pub Date : 2022-03-01 DOI:10.18502/jfrh.v16i1.8588

Farideh Zafari Zangeneh

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引用次数: 1

Abstract

Objective: The purpose of this review was to investigate current knowledge of COVID-19 by highlighting its effect on female reproductive tract. Materials and methods: In this study, all articles related to the effect of SARS, MERS, and CoV-19 viruses on the female reproductive system from 2003 to 2021 were reviewed. Results: The coronavirus enters the host cell by binding to the enzyme that is most abundant in the host lung. The corona or spike (S) protein of this virus is the main tool for binding to the receptor in the host cell membrane and facility the entrance of CoV into the target cells. This receptor is the Angiotensin-Converting Enzyme-2 (ACE2), but the high expression of this receptor can be a mystery to increase infection in host cells. The overexpression of ACE2 in different tissues has a close connection to the severity of this viral infection. Infection in the female reproductive system requires more attention because it may affect the generation and future progeny by damaged gametes. Conclusion: The existing evidence proposes that ACE2 is widely expressed in the reproductive tract includes: ovary, uterus, vagina, and placenta.

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SARS-CoV-2与女性生殖系统中RAS / ACE2的相互作用

目的:通过强调COVID-19对女性生殖道的影响，了解目前对COVID-19的认识。材料与方法:本研究回顾了2003 - 2021年SARS、MERS和CoV-19病毒对女性生殖系统影响的相关文献。结果:冠状病毒通过与宿主肺中最丰富的酶结合进入宿主细胞。冠状病毒的冠状蛋白或刺突蛋白(S)是与宿主细胞膜上的受体结合并促进冠状病毒进入靶细胞的主要工具。这种受体是血管紧张素转换酶-2 (ACE2)，但这种受体的高表达可能是宿主细胞感染增加的一个谜。ACE2在不同组织中的过表达与这种病毒感染的严重程度密切相关。女性生殖系统的感染需要更多的关注，因为它可能通过损坏的配子影响后代和后代。结论:现有证据表明ACE2广泛表达于生殖道，包括卵巢、子宫、阴道和胎盘。

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来源期刊

Journal of Family and Reproductive Health

自引率

0.00%

发文量

审稿时长

5 weeks

期刊介绍： The Journal of Family & Reproductive Health (JFRH) is the quarterly official journal of Vali–e–Asr Reproductive Health Research Center. This journal features fulllength, peerreviewed papers reporting original research, clinical case histories, review articles, as well as opinions and debates on topical issues. Papers published cover the scientific and medical aspects of reproductive physiology and pathology including genetics, endocrinology, andrology, embryology, gynecologic urology, fetomaternal medicine, oncology, infectious disease, public health, nutrition, surgery, menopause, family planning, infertility, psychiatry–psychology, demographic modeling, perinatalogy–neonatolgy ethics and social issues, and pharmacotherapy. A high scientific and editorial standard is maintained throughout the journal along with a regular rate of publication. All published articles will become the property of the JFRH. The editor and publisher accept no responsibility for the statements expressed by the authors here in. Also they do not guarantee, warrant or endorse any product or service advertised in the journal.