{"title":"Comparison of Lapse Rate in Drug Dependent Patients in 2 Methods of Methadone Maintenance Treatment and Buprenorphine Maintenance Treatment.","authors":"Mohammadreza Vafaeinasab, Hamidreza Zare, Ali Dehghani, Seyedehzahra Malek, Maryam Dehghani-Tafti, Mohammadtaghi Sarebanhassanabadi","doi":"10.1177/11782218221112502","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Lapse has been one of the major challenges in the treatment of drug dependence sometimes leading to its relapse.</p><p><strong>Objectives: </strong>The aim of this study was to determine the lapse rate in drug dependent patients as for the 2 methods of methadone maintenance treatment (MMT) and buprenorphine maintenance treatment (BMT) in Yazd city.</p><p><strong>Methods: </strong>In this cross-sectional study, 626 female and male patients who had referred to 5 SUD treatment centers in Yazd and had been treated with methadone and buprenorphine maintenance were studied. Participants were divided into 2 groups of MMT and BMT and were evaluated based on lapse within 6 months.</p><p><strong>Results: </strong>In this study, 60.9% of patients were treated with methadone but the rest were treated with buprenorphine. Overall, 33.1% of patients lapsed (35.2% for methadone and 29.8%for buprenorphine). Lapse in methadone treatment was correlated with age, occupational status, and duration of treatment (<i>P</i> < .05); it failed to correlated with any other demographic and clinical characteristics (<i>P</i> > .05). Lapse rate in buprenorphine treatment was also related to marital status and the drug used (<i>P</i> < .05). The mean dose of buprenorphine consumed showed no significant relationship with lapse (<i>P</i> > .05). The results demonstrated that given the low dose, lapse stood higher in the buprenorphine group than the methadone group; however, as to high dose, the buprenorphine group showed lower lapse than the other group.</p><p><strong>Conclusions: </strong>In regard with the high rate of lapse, it is recommended to consider the factors related to the 2 methods of treatments, and provide counseling and training programs to lower lapse in the patients.<b>Ethics Committee (REC) approval code:</b> IR.SSU.REC.1394.158.</p>","PeriodicalId":22185,"journal":{"name":"Substance Abuse: Research and Treatment","volume":" ","pages":"11782218221112502"},"PeriodicalIF":2.4000,"publicationDate":"2022-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/30/41/10.1177_11782218221112502.PMC9315257.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Substance Abuse: Research and Treatment","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/11782218221112502","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"SUBSTANCE ABUSE","Score":null,"Total":0}
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Abstract
Background: Lapse has been one of the major challenges in the treatment of drug dependence sometimes leading to its relapse.
Objectives: The aim of this study was to determine the lapse rate in drug dependent patients as for the 2 methods of methadone maintenance treatment (MMT) and buprenorphine maintenance treatment (BMT) in Yazd city.
Methods: In this cross-sectional study, 626 female and male patients who had referred to 5 SUD treatment centers in Yazd and had been treated with methadone and buprenorphine maintenance were studied. Participants were divided into 2 groups of MMT and BMT and were evaluated based on lapse within 6 months.
Results: In this study, 60.9% of patients were treated with methadone but the rest were treated with buprenorphine. Overall, 33.1% of patients lapsed (35.2% for methadone and 29.8%for buprenorphine). Lapse in methadone treatment was correlated with age, occupational status, and duration of treatment (P < .05); it failed to correlated with any other demographic and clinical characteristics (P > .05). Lapse rate in buprenorphine treatment was also related to marital status and the drug used (P < .05). The mean dose of buprenorphine consumed showed no significant relationship with lapse (P > .05). The results demonstrated that given the low dose, lapse stood higher in the buprenorphine group than the methadone group; however, as to high dose, the buprenorphine group showed lower lapse than the other group.
Conclusions: In regard with the high rate of lapse, it is recommended to consider the factors related to the 2 methods of treatments, and provide counseling and training programs to lower lapse in the patients.Ethics Committee (REC) approval code: IR.SSU.REC.1394.158.
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