Jonathan J Paly, Mengying Deng, Charles T Lee, Shelly B Hayes, Thomas J Galloway, Mark A Hallman, Stephanie E Weiss, Eric M Horwitz, Robert A Price, C-M Charlie Ma, Joshua E Meyer
{"title":"Pelvic Reirradiation Utilizing Pulsed Low-dose Rate Radiation Therapy.","authors":"Jonathan J Paly, Mengying Deng, Charles T Lee, Shelly B Hayes, Thomas J Galloway, Mark A Hallman, Stephanie E Weiss, Eric M Horwitz, Robert A Price, C-M Charlie Ma, Joshua E Meyer","doi":"10.1097/COC.0000000000000741","DOIUrl":null,"url":null,"abstract":"<p><p>Pulsed low-dose rate radiation therapy has been shown to reduce normal tissue damage while decreasing DNA damage repair in tumor cells. In a cohort of patients treated with palliative or definitive pelvic reirradiation using pulsed low-dose rate radiation therapy, we observed substantial local control and low rates of toxicity.</p>","PeriodicalId":501816,"journal":{"name":"American Journal of Clinical Oncology","volume":" ","pages":"748-751"},"PeriodicalIF":0.0000,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/COC.0000000000000741","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of Clinical Oncology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/COC.0000000000000741","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Pulsed low-dose rate radiation therapy has been shown to reduce normal tissue damage while decreasing DNA damage repair in tumor cells. In a cohort of patients treated with palliative or definitive pelvic reirradiation using pulsed low-dose rate radiation therapy, we observed substantial local control and low rates of toxicity.