Mononucleotide A-repeats may Play a Regulatory Role in Endothermic Housekeeping Genes.

Evolutionary Bioinformatics Online Pub Date : 2022-07-15 eCollection Date: 2022-01-01 DOI:10.1177/11769343221110656

Jatuphol Pholtaisong, Nachol Chaiyaratana, Chatchawit Aporntewan, Apiwat Mutirangura

{"title":"Mononucleotide A-repeats may Play a Regulatory Role in Endothermic Housekeeping Genes.","authors":"Jatuphol Pholtaisong, Nachol Chaiyaratana, Chatchawit Aporntewan, Apiwat Mutirangura","doi":"10.1177/11769343221110656","DOIUrl":null,"url":null,"abstract":"Background: Coding and non-coding short tandem repeats (STRs) facilitate a great diversity of phenotypic traits. The imbalance of mononucleotide A-repeats around transcription start sites (TSSs) was found in 3 mammals: H. sapiens, M. musculus, and R. norvegicus.Principal findings: We found that the imbalance pattern originated in some vertebrates. A similar pattern was observed in mammals and birds, but not in amphibians and reptiles. We proposed that the enriched A-repeats upstream of TSSs is a novel hallmark of endotherms or warm-blooded animals. Gene ontology analysis indicates that the primary function of upstream A-repeats involves metabolism, cellular transportation, and sensory perception (smell and chemical stimulus) through housekeeping genes.Conclusions: Upstream A-repeats may play a regulatory role in the metabolic process of endothermic animals.","PeriodicalId":136690,"journal":{"name":"Evolutionary Bioinformatics Online","volume":" ","pages":"11769343221110656"},"PeriodicalIF":0.0000,"publicationDate":"2022-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c4/87/10.1177_11769343221110656.PMC9290108.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Evolutionary Bioinformatics Online","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1177/11769343221110656","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Coding and non-coding short tandem repeats (STRs) facilitate a great diversity of phenotypic traits. The imbalance of mononucleotide A-repeats around transcription start sites (TSSs) was found in 3 mammals: H. sapiens, M. musculus, and R. norvegicus.

Principal findings: We found that the imbalance pattern originated in some vertebrates. A similar pattern was observed in mammals and birds, but not in amphibians and reptiles. We proposed that the enriched A-repeats upstream of TSSs is a novel hallmark of endotherms or warm-blooded animals. Gene ontology analysis indicates that the primary function of upstream A-repeats involves metabolism, cellular transportation, and sensory perception (smell and chemical stimulus) through housekeeping genes.

Conclusions: Upstream A-repeats may play a regulatory role in the metabolic process of endothermic animals.

Abstract Image

查看原文本刊更多论文

单核苷酸a -重复序列可能在吸热管家基因中起调节作用。

背景:编码和非编码短串联重复序列(STRs)促进了表型性状的多样性。在智人、家鼠和褐家鼠3种哺乳动物中均发现了转录起始位点(tss)周围单核苷酸a -重复序列的不平衡。主要发现:我们发现这种不平衡模式起源于一些脊椎动物。在哺乳动物和鸟类中也观察到了类似的模式，但在两栖动物和爬行动物中却没有。我们认为tss上游富集的a -重复序列是恒温动物或温血动物的新标志。基因本体论分析表明，上游a重复序列的主要功能包括代谢、细胞运输和通过管家基因进行的感觉知觉(嗅觉和化学刺激)。结论:上游a -重复序列可能在吸热动物的代谢过程中起调节作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Evolutionary Bioinformatics Online

自引率

0.00%

发文量