Expression and Significance of Periostin in Tissues and Serum in Oral Leukoplakia and Squamous Cell Carcinoma.

Cancer biotherapy & radiopharmaceuticals Pub Date : 2019-09-01 Epub Date: 2019-06-05 DOI:10.1089/cbr.2018.2764

Wei-Qun Guan, Qun Li, Qi-Ming Ouyang

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引用次数: 5

Abstract

Objective: This study aims to investigate the expression changes of periostin (PN or OSF-2) in oral leukoplakia (OLK) and oral squamous cell carcinoma (OSCC), and analyze its significance in the development of OSCC. Study Design: The expression of periostin was detected from tissue specimens and serum obtained from normal mucosa, OLK and OSCC by immunohistochemistry, enzyme-linked immunosorbent assay, and quantitative polymerase chain reaction. Results: Periostin was significantly overexpressed in OLK and OSCC, when compared with normal controls (p < 0.05). Furthermore, the overexpression of periostin was positively correlated with TNM stage, depth of invasion, and lymph node metastasis (p < 0.05). Conclusion: The overexpression of periostin may be involved in the carcinogenesis process of OLK, which may be used as a marker for detecting OLK. In addition, periostin serum levels can be used as a potential indicator of invasion and a prognosis target for OSCC.

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口腔白斑和鳞状细胞癌组织及血清中骨膜素的表达及意义。

目的:本研究旨在探讨口腔白斑(OLK)和口腔鳞状细胞癌(OSCC)中骨膜蛋白(PN或OSF-2)的表达变化，并分析其在OSCC发生发展中的意义。研究设计:采用免疫组织化学、酶联免疫吸附法和定量聚合酶链反应检测正常黏膜、OLK和OSCC组织标本和血清中骨膜蛋白的表达。结果:与正常对照相比，骨膜蛋白在OLK和OSCC中均显著过表达(p p)。结论:骨膜蛋白的过表达可能参与OLK的癌变过程，可作为检测OLK的标志物。此外，血清骨膜素水平可作为OSCC侵袭的潜在指标和预后指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Cancer biotherapy & radiopharmaceuticals

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