Neutrophilic Dermatosis and Management Strategies for the Inpatient Dermatologist.

IF 2.4 Q2 DERMATOLOGY

Current Dermatology Reports Pub Date : 2022-01-01 Epub Date: 2022-07-16 DOI:10.1007/s13671-022-00364-7

Nishi Shah, Maria S Asdourian, Ted V Jacoby, Steven T Chen

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Abstract

Purpose of review: Neutrophilic dermatoses are a heterogeneous group of disorders with significant overlap in associated conditions, clinical presentation, and histopathologic features. This review provides a structural overview of neutrophilic dermatoses that may present in the inpatient setting along with diagnostic work-up and management strategies.

Recent findings: Sweet's syndrome has been found in patients with coronavirus disease 2019 (COVID-19). Pyoderma gangrenosum (PG) has been shown to be equally associated with ulcerative colitis and Crohn's disease. A clinical trial shows that cyclosporine is equally effective as prednisone in treating PG. Neutrophilic eccrine hidradenitis has been found in the setting of newer antineoplastic medications, such as BRAF inhibitors, as well as in the setting of malignancy without chemotherapy exposure.

Summary: Neutrophilic dermatoses are a rare and complex group of dermatoses with varying and overlapping clinical presentations. Physicians should be aware of the growing list of associated diseases in order to build a better differential diagnosis or to potentially investigate for co-existing disease.

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皮肤科住院医生的嗜中性皮肤病和管理策略。

综述目的：嗜中性粒细胞皮肤病是一组异质性疾病，在相关疾病、临床表现和组织病理学特征方面存在明显重叠。本综述从结构上概述了可能在住院环境中出现的嗜中性皮肤病，以及诊断工作和管理策略：在冠状病毒病 2019（COVID-19）患者中发现了斯威特综合征。脓皮病（PG）已被证明与溃疡性结肠炎和克罗恩病同样相关。一项临床试验显示，环孢素与泼尼松对治疗脓皮病同样有效。在使用 BRAF 抑制剂等新型抗肿瘤药物以及未接受化疗的恶性肿瘤患者中也发现了中性粒细胞性皮炎。医生应了解越来越多的相关疾病，以便更好地进行鉴别诊断或对并存疾病进行潜在调查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Dermatology Reports DERMATOLOGY-

CiteScore

3.30

自引率

6.20%

发文量

期刊介绍： This journal intends to review the most significant recent developments in the field of dermatology. By providing clear, insightful, balanced contributions by expert international authors, the journal aims to serve all those involved in the diagnosis, treatment, management, and prevention of dermatologic conditions. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas across the field, such as epidemiology, surgery, pharmacology, clinical trial design, and pediatrics. Section Editors select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. We also provide commentaries from well-known figures in the field, and an Editorial Board of more than 20 internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research.

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