A putative link between pertussis and new onset of gastroesophageal reflux an observational study.

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Multidisciplinary Respiratory Medicine Pub Date : 2022-07-06 eCollection Date: 2022-01-12 DOI:10.4081/mrm.2022.832

Leticia Burton, Daminda P Weerasinghe, David Joffe, Jennifer Saunders, Gregory L Falk, Hans Van der Wall

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引用次数: 1

Abstract

Background: Pertussis is an infectious disease of the respiratory tract with a changing epidemiology. An increasing incidence has been found in the adult population with recurrent infections possibly related to changes in the current vaccine. Is there an association between pertussis infection, refractory cough and atypical gastro-oesophageal reflux (GORD)? Does this magnify and compound respiratory complications?

Methods: Observational study which compares post-pertussis (n=103) with non-pertussis patients (n=105) with established GORD. Patients were assessed for laryngopharyngeal reflux and aspiration of refluxate by a novel scintigraphic study.

Results: Both groups showed severe GORD in association with high rates of laryngopharyngeal reflux (LPR) and pulmonary aspiration and lung disease. High rates of hiatus hernia and clinical diagnosis of "atypical" asthma showed correlations with pulmonary aspiration.

Conclusions: A high level of new onset LPR and lung aspiration has been shown in patients with chronic cough after recent pertussis infection by a novel scintigraphic technique with fused hybrid x-ray computed tomography (SPECT/CT).

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推测百日咳与胃食管反流新发之间的联系:一项观察性研究。

背景:百日咳是一种流行病学不断变化的呼吸道传染病。在成人人群中发现复发性感染的发病率增加，这可能与当前疫苗的变化有关。百日咳感染、难治性咳嗽和非典型胃食管反流(GORD)之间是否存在关联?这会放大和加重呼吸系统并发症吗?方法:观察性研究，比较百日咳后(n=103)和非百日咳患者(n=105)建立GORD。通过一项新的影像学研究评估患者的咽喉反流和反流误吸。结果:两组患者均出现严重的GORD，并伴有高比例的喉咽反流(LPR)、肺误吸和肺部疾病。裂孔疝的高发率和“非典型”哮喘的临床诊断与肺误吸有关。结论:一种新型融合混合x线计算机断层扫描(SPECT/CT)显示，在近期百日咳感染后的慢性咳嗽患者中，新发LPR和肺误吸水平较高。

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Multidisciplinary Respiratory Medicine Medicine-Pulmonary and Respiratory Medicine

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期刊介绍： Multidisciplinary Respiratory Medicine is the official journal of the Italian Respiratory Society - Società Italiana di Pneumologia (IRS/SIP). The journal publishes on all aspects of respiratory medicine and related fields, with a particular focus on interdisciplinary and translational research. The interdisciplinary nature of the journal provides a unique opportunity for researchers, clinicians and healthcare professionals across specialties to collaborate and exchange information. The journal provides a high visibility platform for the publication and dissemination of top quality original scientific articles, reviews and important position papers documenting clinical and experimental advances.