Vitamin therapy in schizophrenia.

Leonard John Hoffer
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Abstract

Schizophrenia is a devastating and poorly understood disease for which the only accepted therapy is nonspecific antipsychotic and anti-seizure medication. This article summarizes the evidence that certain vitamin deficiencies likely worsen the symptoms of schizophrenia, and the evidence that large doses of certain vitamins could improve the core metabolic abnormalities that predispose some people to develop it; it recounts the history of a controversial vitamin-based therapy for schizophrenia called orthomolecular psychiatry; and it concludes by advocating a process for discovering promising new schizophrenia therapies that involves small, carefully conducted clinical trials of nutrient combinations in appropriately selected patients.

精神分裂症的维生素治疗。
精神分裂症是一种毁灭性的疾病,人们对其知之甚少,唯一接受的治疗方法是非特异性抗精神病和抗癫痫药物。这篇文章总结了以下证据:某些维生素缺乏可能会加重精神分裂症的症状,而大剂量的某些维生素可以改善一些人易患精神分裂症的核心代谢异常;它讲述了一种有争议的以维生素为基础的精神分裂症治疗方法——正分子精神病学的历史;最后,它提倡一种发现有希望的精神分裂症新疗法的过程,包括在适当选择的患者中进行小规模、精心进行的营养组合临床试验。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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