Study of the relationship between FT3, FT4, and TSH with bone resorption indices in men with hypothyroidism.

Journal of population therapeutics and clinical pharmacology = Journal de la therapeutique des populations et de la pharmacologie clinique Pub Date : 2022-06-16 eCollection Date: 2022-01-01 DOI:10.47750/jptcp.2022.929

Asma'a H Mohamed, Noor S Naji, Ali H Al-Saadi

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Abstract

Aim: This study aimed to find the effect of hypothyroidism in men on metabolism and bone mineral density.

Method: The study included a patients group of 90 men suffering from hypothyroidism and 120 healthy subjects as a control group. The study comprised the estimation of the concentration of Blood free triiodothyronine (FT3), free thyroid hormone (FT4), thyroid stimulating hormone (TSH), bone resorption index type I collagen C-terminal peptide (CTX-1), the serum calcium (Ca2+), serum phosphorus (Pi3+), the bone mineral density of the lumbar spine and femoral neck.

Results: In the hypothyroidism men group: (1) the bone mass was lower than the control group with significant differences, (2) the bone resorption index CTX-1 was significantly higher than that in the control group and calcium and phosphorus were not different from those in healthy control subjects, and (3) TSH was positively correlated with CTX-1. Male TSH and CTX-1 levels were positively correlated.

Conclusions: There is bone loss in men with hypothyroidism, which may be related to increased bone resorption.

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甲状腺功能减退症患者FT3、FT4、TSH与骨吸收指标关系的研究

目的:探讨男性甲状腺功能减退症对人体代谢及骨密度的影响。方法:以男性甲状腺功能减退患者90例为研究对象，以健康人群120例为对照组。研究包括血游离三碘甲状腺原氨酸(FT3)、游离甲状腺激素(FT4)、促甲状腺激素(TSH)、骨吸收指数I型胶原c末端肽(CTX-1)、血清钙(Ca2+)、血清磷(Pi3+)、腰椎和股骨颈骨密度的测定。结果:甲状腺功能减退男性组:(1)骨量低于对照组，差异有统计学意义;(2)骨吸收指数CTX-1显著高于对照组，钙、磷与健康对照组无显著差异;(3)TSH与CTX-1呈正相关。男性TSH与CTX-1水平呈正相关。结论:甲状腺功能减退患者存在骨质流失，这可能与骨吸收增加有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of population therapeutics and clinical pharmacology = Journal de la therapeutique des populations et de la pharmacologie clinique

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