[Role of matrix glycoproteins during chondrocyte differentiation (author's transl)].

Abstract

The importance of cell-matrix interactions during terminal chondrocyte differentiation is to-day accepted by all authors. Na-hyaluronate micro-injections induce an increase of perichondral thickness and maintain mesenchymal aspect in chondrocyte. Cytoplasmic organelles show anomalies which may be bound to disturbance in cellular metabolism. An important decrease of matrix-constituents is observed, a fact showing that high hyaluronate concentration interferes with chondroitin-sulfate synthesis or secretion and collagen organization.