{"title":"Modeling malaria transmission in Nepal: impact of imported cases through cross-border mobility.","authors":"Ramesh Gautam, Anjana Pokharel, Khagendra Adhikari, Kedar Nath Uprety, Naveen K Vaidya","doi":"10.1080/17513758.2022.2096935","DOIUrl":null,"url":null,"abstract":"<p><p>The cross-border mobility of malaria cases poses an obstacle to malaria elimination programmes in many countries, including Nepal. Here, we develop a novel mathematical model to study how the imported malaria cases through the Nepal-India open-border affect the Nepal government's goal of eliminating malaria by 2026. Mathematical analyses and numerical simulations of our model, validated by malaria case data from Nepal, indicate that eliminating malaria from Nepal is possible if strategies promoting the absence of cross-border mobility, complete protection of transmission abroad, or strict border screening and isolation are implemented. For each strategy, we establish the conditions for the elimination of malaria. We further use our model to identify the control strategies that can help maintain a low endemic level. Our results show that the ideal control strategies should be designed according to the average mosquito biting rates that may depend on the location and season.</p>","PeriodicalId":48809,"journal":{"name":"Journal of Biological Dynamics","volume":" ","pages":"528-564"},"PeriodicalIF":2.7000,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Biological Dynamics","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1080/17513758.2022.2096935","RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ECOLOGY","Score":null,"Total":0}
引用次数: 1
Abstract
The cross-border mobility of malaria cases poses an obstacle to malaria elimination programmes in many countries, including Nepal. Here, we develop a novel mathematical model to study how the imported malaria cases through the Nepal-India open-border affect the Nepal government's goal of eliminating malaria by 2026. Mathematical analyses and numerical simulations of our model, validated by malaria case data from Nepal, indicate that eliminating malaria from Nepal is possible if strategies promoting the absence of cross-border mobility, complete protection of transmission abroad, or strict border screening and isolation are implemented. For each strategy, we establish the conditions for the elimination of malaria. We further use our model to identify the control strategies that can help maintain a low endemic level. Our results show that the ideal control strategies should be designed according to the average mosquito biting rates that may depend on the location and season.
期刊介绍：
Journal of Biological Dynamics, an open access journal, publishes state of the art papers dealing with the analysis of dynamic models that arise from biological processes. The Journal focuses on dynamic phenomena at scales ranging from the level of individual organisms to that of populations, communities, and ecosystems in the fields of ecology and evolutionary biology, population dynamics, epidemiology, immunology, neuroscience, environmental science, and animal behavior. Papers in other areas are acceptable at the editors’ discretion. In addition to papers that analyze original mathematical models and develop new theories and analytic methods, the Journal welcomes papers that connect mathematical modeling and analysis to experimental and observational data. The Journal also publishes short notes, expository and review articles, book reviews and a section on open problems.
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