Pharmacogenetic testing in pediatric neurology: a pragmatic study evaluating clinician and patient perceptions.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2022-09-01 Epub Date: 2022-07-13 DOI:10.2217/pme-2021-0150

Marie-Anne Pépin, Anne-Sophie Otis, Zoë Tremblay, Marianne Boulé, Denis Lebel, Philippe Major, Anne Lortie, Elana Pinchefsky, Elsa Rossignol, Bruce Carleton, Jean-François Bussières, Marie-Élaine Métras

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引用次数: 0

Abstract

Aim: To evaluate clinicians' and patients' perceptions of pharmacogenetic testing in a clinical setting. Materials & methods: This is a pragmatic mixed-method prospective observational study. Hospital pharmacists and neurologists participated in focus groups regarding pharmacogenetic testing; patients who received pharmacogenetic testing and their community pharmacists completed surveys to assess their perception of these tests. Results: Most study participants had a positive view of pharmacogenetic testing. Three major themes were identified from the focus groups: receptiveness to pharmacogenetic testing, pharmacogenetic test characteristics and integrating pharmacogenetic tests into practice. Conclusion: The views reported are encouraging for the eventual implementation of pharmacogenetics in practice. Local integration of these tests is an essential step to improve patient care through personalized medicine.

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儿童神经病学的药物遗传学测试:一项评估临床医生和患者认知的实用研究。

目的:评价临床医生和患者对临床环境中药物遗传学检测的看法。材料与方法:这是一项实用的混合方法前瞻性观察研究。医院药剂师和神经科医生参加了关于药物遗传学检测的焦点小组;接受药物遗传学检测的患者及其社区药剂师完成了调查，以评估他们对这些检测的看法。结果:大多数研究参与者对药物遗传学检测持积极态度。焦点小组确定了三个主要主题:对药物遗传测试的接受程度、药物遗传测试的特点和将药物遗传测试纳入实践。结论:报告的观点对药物遗传学在实践中的最终实施是令人鼓舞的。在当地整合这些检测是通过个性化医疗改善患者护理的重要一步。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.