Implications of peritoneal cancer index distribution on patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy.

IF 1.4 Q4 ONCOLOGY

Pleura and Peritoneum Pub Date : 2022-04-26 eCollection Date: 2022-06-01 DOI:10.1515/pp-2021-0150

Jolene Si Min Wong, Grace Hwei Ching Tan, Sabrina Hui Xian Cheok, Chin-Ann Johnny Ong, Claramae Shulyn Chia, Melissa Ching Ching Teo

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引用次数: 1

Abstract

Objectives: Peritoneal cancer index (PCI) score is a common prognostication tool in peritoneal metastases (PM). We hypothesize that the distribution of PCI score and involvement of specific regions affects survival and morbidity outcomes.

Methods: Data was collected from a prospective database of patients who underwent CRS and HIPEC for PM at the National Cancer Centre Singapore. We evaluate the relationship between PCI, PCI distribution, and survival and morbidity outcomes.

Results: One hundred and fifty-two patients underwent CRS and HIPEC with a median PCI score of nine (range 0-31). Median overall survival (OS) and progression free survival (PFS) were 43 and 17 months, respectively. Region six (pelvis) was most commonly involved and had the highest frequency of heavy disease burden. Presence of PM in the lower abdomen, flanks, and small bowel were associated with poorer OS (p=0.01, 0.03, <0.001) and PFS (p=0.04, 0.02, <0.001). Involvement of porta hepatitis predicted poorer OS but not PFS (p=0.03). Involvement of the gastric antrum resulted in higher rates of postoperative complications.

Conclusions: The pattern of PCI distribution may be associated with varying survival and morbidity outcomes.

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腹膜癌指数分布对行细胞减缩手术及腹腔热化疗患者的影响。

目的:腹膜癌指数(PCI)评分是腹膜转移(PM)的常用预后工具。我们假设PCI评分的分布和特定区域的受累影响生存和发病率结果。方法:数据来自新加坡国家癌症中心接受CRS和HIPEC治疗PM患者的前瞻性数据库。我们评估了PCI、PCI分布、生存和发病率结果之间的关系。结果:152例患者接受了CRS和HIPEC, PCI评分中位数为9分(范围0-31)。中位总生存期(OS)和无进展生存期(PFS)分别为43个月和17个月。第6区(骨盆)最常受累，疾病负担重的频率最高。下腹部、侧腹和小肠存在PM与较差的OS相关(p=0.01, 0.03)。结论:PCI分布模式可能与不同的生存和发病率结果相关。

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