Gut Microbiota-Assisted Synthesis, Cellular Interactions and Synergistic Perspectives of Equol as a Potent Anticancer Isoflavone.

Hardeep Singh Tuli, Ajay Kumar, Katrin Sak, Diwakar Aggarwal, Dhruv Sanjay Gupta, Ginpreet Kaur, Kanupriya Vashishth, Kuldeep Dhama, Jagjit Kaur, Adesh K Saini, Mehmet Varol, Esra Capanoglu, Shafiul Haque
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引用次数: 6

Abstract

It is well known that, historically, plants have been an important resource of anticancer agents, providing several clinically approved drugs. Numerous preclinical studies have shown a strong anticancer potential of structurally different phytochemicals, including polyphenolic constituents of plants, flavonoids. In this review article, suppressing effects of equol in different carcinogenesis models are unraveled, highlighting the mechanisms involved in these anticancer activities. Among flavonoids, daidzein is a well-known isoflavone occurring in soybeans and soy products. In a certain part of population, this soy isoflavone is decomposed to equol under the action of gut microflora. Somewhat surprisingly, this degradation product has been shown to be more bioactive than its precursor daidzein, revealing a strong and multifaceted anticancer potential. In this way, it is important to bear in mind that the metabolic conversion of plant flavonoids might lead to products that are even more efficient than the parent compounds themselves, definitely deserving further studies.

Abstract Image

Abstract Image

Abstract Image

肠道微生物辅助合成、细胞相互作用及马雌酚作为强效抗癌异黄酮的协同作用。
众所周知,从历史上看,植物一直是抗癌药物的重要来源,提供了几种临床批准的药物。大量的临床前研究表明,结构不同的植物化学物质具有很强的抗癌潜力,包括植物的多酚成分,类黄酮。在这篇综述文章中,马雌酚在不同的癌症发生模型中的抑制作用被揭示,并强调了这些抗癌活性的机制。黄酮类化合物中,大豆黄酮是一种众所周知的异黄酮,存在于大豆和大豆制品中。在一定人群中,这种大豆异黄酮在肠道菌群的作用下分解为雌马酚。令人惊讶的是,这种降解产物已被证明比其前体大豆苷元更具生物活性,显示出强大的多方面抗癌潜力。因此,重要的是要记住,植物类黄酮的代谢转化可能会产生比母体化合物本身更有效的产品,这绝对值得进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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