Establishment of gender- and age-specific reference intervals for serum liver function tests among the elderly population in northeast China: a retrospective study.

IF 3.8 3区 医学 Q1 MEDICAL LABORATORY TECHNOLOGY
Zeyu Sun, Jiatong Chai, Qi Zhou, Jiancheng Xu
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引用次数: 3

Abstract

Introduction: Reference intervals (RIs) for younger population may not apply to the elderly population. The aim of this study was to establish gender- and age-specific RIs for serum liver function tests among the elderly population and to compare with younger population RIs currently used in China and other countries.

Materials and methods: This was a retrospective study, and subjects (≥ 18 year-old) were recruited from the laboratory information system (LIS) at the First Hospital of Jilin University between April 2020 and April 2021. The following parameters were collected: aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyltransferase (GGT), alkaline phosphatase (ALP), total protein (TP), albumin (ALB), total bilirubin (TBIL), and direct bilirubin (DBIL). The Tukey method was used to eliminate outliers. Reference intervals were established by the nonparametric method.

Results: A total of 23,597 healthy individuals were enrolled in the study. From all parameters AST, ALT, TP and ALB required no gender partition, while ALT, GGT, TP, ALB and DBIL required different partitions for age. Activities and concentrations of ALT, ALB, and TP showed a downward trend in the elderly aged 60-89. In contrast, DBIL showed a gradual upward trend.

Conclusion: The RIs for liver function tests among healthy elderly population were different from those among young population in China. There were apparent gender and age differences in the RIs of liver function for elderly and significant differences compared with national standards and RIs in other countries. Therefore, it is necessary to establish gender- and age-specific RIs for serum liver function tests among the elderly population.

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东北地区老年人群血清肝功能检测的性别和年龄特异性参考区间的建立:一项回顾性研究
引言:年轻人群的参考区间(RIs)可能不适用于老年人群。本研究的目的是在老年人群中建立血清肝功能检测的性别和年龄特异性RIs,并与目前在中国和其他国家使用的年轻人群RIs进行比较。材料与方法:本研究为回顾性研究,受试者年龄≥18岁,于2020年4月至2021年4月从吉林大学第一医院实验室信息系统(LIS)中招募。采集以下参数:天冬氨酸转氨酶(AST)、丙氨酸转氨酶(ALT)、γ -谷氨酰转移酶(GGT)、碱性磷酸酶(ALP)、总蛋白(TP)、白蛋白(ALB)、总胆红素(TBIL)、直接胆红素(DBIL)。采用Tukey法剔除异常值。采用非参数方法建立参考区间。结果:共有23,597名健康个体参加了这项研究。从各参数看,AST、ALT、TP和ALB不需要性别分区,ALT、GGT、TP、ALB和DBIL需要根据年龄进行不同分区。60 ~ 89岁老年人ALT、ALB、TP活性及浓度均呈下降趋势。相比之下,DBIL呈逐渐上升趋势。结论:中国健康老年人群肝功能检测RIs与年轻人群存在差异。老年人肝功能RIs存在明显的性别、年龄差异,与国家标准及其他国家RIs相比差异显著。因此,有必要在老年人群中建立血清肝功能检测的性别和年龄特异性RIs。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biochemia Medica
Biochemia Medica 医学-医学实验技术
CiteScore
5.50
自引率
3.00%
发文量
70
审稿时长
>12 weeks
期刊介绍: Biochemia Medica is the official peer-reviewed journal of the Croatian Society of Medical Biochemistry and Laboratory Medicine. Journal provides a wide coverage of research in all aspects of clinical chemistry and laboratory medicine. Following categories fit into the scope of the Journal: general clinical chemistry, haematology and haemostasis, molecular diagnostics and endocrinology. Development, validation and verification of analytical techniques and methods applicable to clinical chemistry and laboratory medicine are welcome as well as studies dealing with laboratory organization, automation and quality control. Journal publishes on a regular basis educative preanalytical case reports (Preanalytical mysteries), articles dealing with applied biostatistics (Lessons in biostatistics) and research integrity (Research integrity corner).
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