Hydrogel-based dressings in the treatment of partial thickness experimentally induced burn wounds in rats.

IF 1.1 4区医学 Q3 SURGERY

Acta cirurgica brasileira Pub Date : 2022-07-01 eCollection Date: 2022-01-01 DOI:10.1590/acb370401

Milton Junior Cândido Bernardes, Randys Caldeira Gonçalves, Carolyna de Sousa Carvalho, Luciana Martins Rosa, Amanda Peixoto Ferreira, Marielle Sousa Vilela, Marina Clare Vinaud, Hélio Galdino Junior, Ruy de Souza Lino Junior

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引用次数: 1

Abstract

Purpose: To compare four commercially available hydrogel formulations in the healing of partial thickness burns experimentally induced in rats.

Methods: Wistar rats were used, and after the burn wound induction they were divided into the following treatment groups: G1) NaCl 0.9%; G2) 1% silver sulfadiazine; G3) Debrigel™; G4) Safgel™; G5) Dersani™; G6) Solosite™. The animals were followed during seven, 14 and 30 days after the injury induction. Morphometric, macroscopic and microscopic evaluations were performed.

Results: The treatment with Dersani™ induced better results during the inflammatory and proliferative phases of the healing process (p<0.05). The animals treated with Safgel™ presented better scaring in the remodeling phase (p<0.05), and the treatment with Dersani™ and Solosite™ induced greater wound closure (p<0.05).

Conclusions: The hydrogel-based dressings presented beneficial outcomes in the healing of burn wounds experimentally induced in rats due to their ability in maintain the humidity of the wound, in removing the exudate, in promoting cell migration and collagen production during the different phases of the healing process.

Abstract Image

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水凝胶基敷料治疗实验性大鼠部分厚度烧伤创面。

目的:比较4种市售水凝胶配方对实验性大鼠局部烧伤愈合的影响。方法:选用Wistar大鼠，烧伤创面诱导后分为以下处理组:G1) NaCl 0.9%;G2) 1%磺胺嘧啶银;G3) Debrigel™;G4) Safgel™;G5) Dersani™;G6) Solosite™。分别于诱导伤后7、14、30 d进行随访。形态学、宏观和微观评价。结果:Dersani™治疗在愈合过程的炎症和增殖阶段均有较好的效果。结论:水凝胶敷料在大鼠实验性烧伤创面的愈合过程中具有保持创面湿度、清除渗出液、促进细胞迁移和胶原蛋白生成的作用。

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来源期刊

Acta cirurgica brasileira 医学-外科

CiteScore

1.90

自引率

9.10%

发文量

审稿时长

3-8 weeks

期刊介绍： Information not localized