The lncRNA-miRNA-integrin alpha V ceRNA network can affect the occurrence and prognosis of gastric cancer.

IF 1.1 Q4 ONCOLOGY

International journal of clinical and experimental pathology Pub Date : 2022-10-15 eCollection Date: 2022-01-01

Ze-Zhong Chen, Wen-Peng Wang, Hong-Mei Xue, Yu Liang

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引用次数: 0

Abstract

Objectives: The aim of this study was to explore the role of integrin alpha V (ITGAV) and the related long noncoding RNA-microRNA-messenger RNA competing endogenous RNA (lncRNA-miRNA-mRNA ceRNA) network in the development and prognosis of cancers, especially gastric cancer (GC), through bioinformatic analysis.

Methods: Pan-cancer and GC data were collected from the UCSC Xena website, and validation datasets were obtained from the Gene Expression Omnibus (GEO). R (version 3.6.3), GraphPad Prism 8, and SPSS 23.0 software were used to analyze data and prepare figures.

Results: The expression of ITGAV in tumor tissues was higher than that of normal tissues in ten cancer types. A lower expression of ITGAV in five tumors (CESC, LGG, LIHC, MESO, and STAD) predicted better patient prognosis. In GC, the mRNA and protein expression of ITGAV in tumor tissues was higher than that of normal tissues. Patients with high ITGAV expression had poor prognosis and clinical characteristics, including worse grades and more advanced stages. Patients with higher ITGAV expression had higher immune and stromal scores and lower purity (P<0.05). In addition, seven miRNAs were found that were negatively correlated with ITGAV expression through the website; high expression of these miRNAs indicated a better prognosis. Using this correlation, the authors built the lncRNA-miRNA-ITGAV ceRNA network, to predict the prognosis of GC.

Conclusions: This study showed that ITGAV could be considered a prognostic factor for GC, and an lncRNA-miRNA-ITGAV ceRNA network was built to promote the exploration of the mechanism and prognosis of GC.

本刊更多论文

lncRNA-miRNA-integrin α V ceRNA网络可影响胃癌的发生和预后。

目的:本研究旨在通过生物信息学分析，探讨整合素α V (ITGAV)及其相关的长链非编码RNA- microrna -信使RNA竞争内源性RNA (lncRNA-miRNA-mRNA ceRNA)网络在癌症，特别是胃癌(GC)的发展和预后中的作用。方法:Pan-cancer和GC数据来源于UCSC Xena网站，验证数据来源于Gene Expression Omnibus (GEO)。采用R (version 3.6.3)、GraphPad Prism 8、SPSS 23.0软件进行数据分析和图表制作。结果:10种肿瘤组织中ITGAV的表达均高于正常组织。ITGAV在5种肿瘤(CESC、LGG、LIHC、MESO和STAD)中的低表达预示着更好的预后。在胃癌中，肿瘤组织中ITGAV mRNA和蛋白的表达均高于正常组织。ITGAV高表达的患者预后和临床特征较差，包括较差的分级和较晚期。结论:本研究提示ITGAV可能是胃癌的预后因素之一，构建lncRNA-miRNA-ITGAV ceRNA网络，促进对胃癌发病机制及预后的探讨。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International journal of clinical and experimental pathology ONCOLOGY-PATHOLOGY

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： The International Journal of Clinical and Experimental Pathology (IJCEP, ISSN 1936-2625) is a peer reviewed, open access online journal. It was founded in 2008 by an international group of academic pathologists and scientists who are devoted to the scientific exploration of human disease and the rapid dissemination of original data. Unlike most other open access online journals, IJCEP will keep all the traditional features of paper print that we are all familiar with, such as continuous volume and issue numbers, as well as continuous page numbers to keep our warm feelings towards an academic journal. Unlike most other open access online journals, IJCEP will keep all the traditional features of paper print that we are all familiar with, such as continuous volume and issue numbers, as well as continuous page numbers to keep our warm feelings towards an academic journal.