Prescription of benzodiazepines and Z-drugs among older patients in primary care: a French, national, cohort study.

IF 2.4 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Jonathan Yana, Laura Moscova, Julien Le Breton, Emmanuelle Boutin, Tiphaine Siess, Pascal Clerc, Sylvie Bastuji-Garin, Emilie Ferrat
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引用次数: 0

Abstract

Background: In France, general practitioners (GPs) prescribe benzodiazepines and Z-drugs (BZD/ZDs) widely, and especially to older adults. Several characteristics of patients and/or GPs linked to BZD/ZD overprescription have been described in the general population but not among older patients in primary care.

Objectives: To estimate the proportion of GP consultations by patients aged 65 and over that resulted in a BZD/ZD prescription, and determine whether any GP-related factors predicted BZD/ZD overprescription in this setting.

Methods: We analyzed sociodemographic and practice-related GP characteristics, and aggregated data on consultations recorded prospectively by 117 GPs in a database between 2000 and 2010. Next, we used logistic regression models to look for factors potentially associated with BZD/ZD overprescription (defined as an above-median prescription rate).

Results: The GPs' mean age at inclusion was 47.4 (7.1), and 87.9% were male. During the study period, the median (95% confidence interval) proportion of consultations with patients aged 65 and over resulting in a BZD/ZD prescription was 21.8% (18.1-26.1) (range per GP: 5-34.1%). In a multivariable analysis, a greater number of chronic disease (OR [95% CI] = 2.10 [1.22-3.64]), a greater number of drugs prescribed per consultation (5.29 [2.72-10.28]), and shorter study participation were independently associated with BZD/ZD overprescription.

Conclusions: BZD/ZD overprescription was associated with a greater chronic disease burden and the number of drugs prescribed per consultation but not with any sociodemographic or practice-related GP characteristics. Targeted actions are needed to help GPs limit their prescription of BZD/ZDs to older patients with multiple comorbidities and polypharmacy.

初级保健中老年患者苯二氮卓类药物和 Z 类药物的处方:一项法国全国性队列研究。
背景:在法国,全科医生(GPs)广泛开具苯二氮卓类药物和Z类药物(BZD/ZDs)处方,尤其是针对老年人。在普通人群中,患者和/或全科医生的一些特征与BZD/ZD超量处方有关,但在初级医疗机构的老年患者中却没有描述:目的:估算 65 岁及以上患者接受全科医生咨询后开出 BZD/ZD 处方的比例,并确定在这种情况下是否有任何全科医生相关因素可预测 BZD/ZD 的超量处方:我们分析了全科医生的社会人口学特征和执业相关特征,并汇总了数据库中 117 名全科医生在 2000 年至 2010 年间记录的前瞻性咨询数据。然后,我们使用逻辑回归模型来寻找与BZD/ZD超量处方(定义为处方率高于中位数)相关的潜在因素:全科医生入选时的平均年龄为 47.4 (7.1)岁,87.9% 为男性。在研究期间,65 岁及以上患者就诊时开出 BZD/ZD 处方的比例中位数(95% 置信区间)为 21.8%(18.1-26.1)(每位全科医生的比例范围为 5-34.1%)。在一项多变量分析中,慢性病数量越多(OR [95% CI] = 2.10 [1.22-3.64])、每次问诊开出的药物数量越多(5.29 [2.72-10.28])以及参与研究的时间越短,均与BZD/ZD超量处方独立相关:结论:BZD/ZD超量处方与慢性病负担加重和每次就诊处方药物数量有关,但与任何社会人口学特征或全科医生执业相关特征无关。需要采取有针对性的行动,帮助全科医生限制向患有多种并发症和多种药物的老年患者开具BZD/ZD处方。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Family practice
Family practice 医学-医学:内科
CiteScore
4.30
自引率
9.10%
发文量
144
审稿时长
4-8 weeks
期刊介绍: Family Practice is an international journal aimed at practitioners, teachers, and researchers in the fields of family medicine, general practice, and primary care in both developed and developing countries. Family Practice offers its readership an international view of the problems and preoccupations in the field, while providing a medium of instruction and exploration. The journal''s range and content covers such areas as health care delivery, epidemiology, public health, and clinical case studies. The journal aims to be interdisciplinary and contributions from other disciplines of medicine and social science are always welcomed.
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