Effect of non-surgical periodontal treatment on gingival crevicular fluid and serum leptin levels in periodontally healthy chronic periodontitis and chronic periodontitis patients with type 2 diabetes mellitus

Q1 Medicine

Journal of Investigative and Clinical Dentistry Pub Date : 2019-06-06 DOI:10.1111/jicd.12420

Charu R. Ahuja, Abhay P. Kolte, Rajashri A. Kolte, Madhur Gupta, Suresh Chari

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引用次数: 9

Abstract

Aim

The aim of the present study was to evaluate the effect of non-surgical periodontal therapy (NSPT) on gingival crevicular fluid (GCF) and serum leptin levels and glycemic status in periodontally healthy patients with chronic periodontitis (CP) with and without type 2 diabetes mellitus (T2DM).

Methods

Ninety patients were divided into three groups: periodontally healthy (group 1), CP (group 2) and CP with T2DM (group 3). The groups were evaluated for clinical parameters of probing pocket depth (PPD), clinical attachment level (CAL), plaque index, gingival index, biochemical parameters of GCF, serum leptin levels, and glycemic status pre- and post-NSPT.

Results

The baseline PPD and CAL for group 2 was 4.98 ± 0.49 mm and 5.35 ± 0.55 mm, respectively; for group 3 it was 5.60 ± 0.38 mm and 6.01 ± 0.38 mm, respectively. There was a considerable reduction in these parameters post-NSPT, with group 2 showing better resolution. Pretreatment serum leptin levels revealed increasing values from group 1 to group 3 and decreasing GCF values from group 3 to group 1, exhibiting an inverse relationship. Group 3 also showed an improvement in glycemic status post-NSPT.

Conclusion

NSPT was effective in improving clinical parameters, increasing GCF, reducing serum leptin levels, and also improving glycemic status in patients with CP and CP with T2DM.

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牙周非手术治疗对牙周健康慢性牙周炎和慢性牙周炎合并2型糖尿病患者龈沟液及血清瘦素水平的影响

目的探讨非手术牙周治疗(NSPT)对伴有和不伴有2型糖尿病(T2DM)的慢性牙周炎(CP)患者龈沟液(GCF)、血清瘦素水平及血糖水平的影响。方法将90例患者分为牙周健康组(1组)、CP组(2组)和CP合并T2DM组(3组)，对各组患者进行探查袋深度(PPD)、临床附着水平(CAL)、菌斑指数、牙龈指数、GCF生化指标、血清瘦素水平、nspt前后血糖状态等临床指标的评估。结果2组基线PPD和CAL分别为4.98±0.49 mm和5.35±0.55 mm;3组分别为5.60±0.38 mm和6.01±0.38 mm。nspt后这些参数有相当大的降低，2组表现出更好的分辨率。预处理后血清瘦素水平从1组升高到3组，GCF值从3组降低到1组，呈反比关系。第三组在nspt后血糖状况也有所改善。结论NSPT可改善CP及CP合并T2DM患者的临床参数，提高GCF，降低血清瘦素水平，改善血糖状态。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Investigative and Clinical Dentistry DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.90

自引率

0.00%

发文量

期刊介绍： Journal of Investigative and Clinical Dentistry (JICD) aims to publish quality, peer reviewed original research and topical reviews on all aspects of investigative and clinical dentistry and craniofacial research, including molecular studies related to oral health and disease. Although international in outlook, the Editor especially encourages papers from the Asia Pacific. The journal also aims to provide clinicians, scientists and students of dentistry with a knowledge transfer platform for rapid publication of reports through an international journal, which will be available free online until 2012. Its scope, therefore, is broad, inclusive and international, but with a particular focus on Asia Pacific. The Editor welcomes manuscripts in the following key thematic areas in oral and maxillofacial sciences: Community Dentistry and Oral Epidemiology, Conservative Dentistry, Dental Biomaterials, Dental Pedagogy, Endodontics and Traumatology, Implant Dentistry, Oral Biosciences, Oral and Maxillofacial Surgery, Oral Medicine, Oral Pathology and Oral Microbiology, Orthodontics, Oral Radiology, Oral Rehabilitation, Paedodontics, Periodontology and Periodontal Medicine.