Association of XRCC3 18067 C>T (Thr241Met) polymorphism with risk of cervical and ovarian cancers: A systematic review and meta-analysis.

Q2 Medicine

Interventional Medicine and Applied Science Pub Date : 2019-10-07 eCollection Date: 2020-09-01 DOI:10.1556/1646.11.2019.21

Mojgan Karimi-Zarchi, Mansour Moghimi, Hajar Abbasi, Amaneh Hadadan, Razieh-Sadat Tabatabaei, Atiyeh Javaheri, Hossein Neamatzadeh

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引用次数: 2

Abstract

The 18067 C>T polymorphism of XRCC3 gene has been considered to be implicated in the development of cervical and ovarian cancers, but the results are inconsistent. Thus, we conducted a meta-analysis to assess the association of XRCC3 18067 C>T polymorphism with risk of cervical and ovarian cancers. All studies on the association of XRCC3 18067 C>T polymorphism with cervical and ovarian cancers risk were retrieved. Finally, a total of 17 studies including 10 studies with 5,637 cases and 10,057 controls on ovarian cancer and 7 studies with 1,112 cases and 1,233 controls on cervical cancer were selected. Overall, pooled results showed that the XRCC3 18067 C>T polymorphism was significantly associated with increased risk of ovarian cancer (TC vs. CC: OR = 0.904, 95% CI = 0.841-0.972, p = 0.006; TT + TC vs. CC: OR = 0.914, 95% CI = 0.853-0.979, p = 0.010) and cervical cancer (TC vs. CC: OR = 1.00, 95% CI = 1.066-1.585, p = 0.009). Further subgroup analysis by ethnicity revealed an increased risk of cervical and ovarian cancer in Asians and Caucasians, respectively. The present meta-analysis inconsistent with the previous meta-analysis suggests that the XRCC3 18067 C>T polymorphism might be implicated in the pathogenesis of cervical and ovarian cancers.

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XRCC3 18067 C>T (Thr241Met)多态性与宫颈癌和卵巢癌风险的关联:一项系统综述和荟萃分析

XRCC3基因18067 C>T多态性被认为与宫颈癌和卵巢癌的发生有关，但结果并不一致。因此，我们进行了一项荟萃分析，以评估XRCC3 18067 C>T多态性与宫颈癌和卵巢癌风险的关系。检索所有关于XRCC3 18067 C>T多态性与宫颈癌和卵巢癌风险相关性的研究。最后，总共选择了17项研究，包括10项研究，5,637例卵巢癌和10,057例对照，以及7项研究，1,112例宫颈癌和1,233例对照。总体而言，汇总结果显示，XRCC3 18067 C>T多态性与卵巢癌风险增加显著相关(TC vs CC: OR = 0.904, 95% CI = 0.841-0.972, p = 0.006;TT + TC与CC: = 0.914, 95% CI -0.979 = 0.853, p = 0.010)和宫颈癌(TC与CC: = 1.00, 95% CI -1.585 = 1.066, p = 0.009)。进一步的种族亚组分析显示，亚洲人和白种人患宫颈癌和卵巢癌的风险分别增加。本荟萃分析结果与前期荟萃分析结果不一致，提示XRCC3 18067 C>T多态性可能与宫颈癌和卵巢癌的发病机制有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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