Mahvand Sadeghi, Richard Loftus, Constantin A Dasanu
{"title":"Erlotinib-Induced Transverse Fissure-Like Skin Lesions of Fingers.","authors":"Mahvand Sadeghi, Richard Loftus, Constantin A Dasanu","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Erlotinib is an epidermal growth factor receptor tyrosine kinase (EGFR-TK) antagonist used in the therapy of non-small cell lung cancer. This agent has been associated with several dermatologic side effects, the most common being acneiform rash involving the face, neck, chest, and back. The occurrence of skin side effects has been correlated with both therapeutic efficacy and increased overall survival in these patients. We report herein unusual erlotinib-induced skin lesions affecting fingers, with a transverse fissure-like appearance and beefy-red laceration-like center. A unique feature is their location on adductor surfaces and more proximal aspects of the phalanges. This erlotinib side effect has not been previously reported in the medical literature.</p>","PeriodicalId":35577,"journal":{"name":"Connecticut Medicine","volume":"80 7","pages":"405-407"},"PeriodicalIF":0.0000,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Connecticut Medicine","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Erlotinib is an epidermal growth factor receptor tyrosine kinase (EGFR-TK) antagonist used in the therapy of non-small cell lung cancer. This agent has been associated with several dermatologic side effects, the most common being acneiform rash involving the face, neck, chest, and back. The occurrence of skin side effects has been correlated with both therapeutic efficacy and increased overall survival in these patients. We report herein unusual erlotinib-induced skin lesions affecting fingers, with a transverse fissure-like appearance and beefy-red laceration-like center. A unique feature is their location on adductor surfaces and more proximal aspects of the phalanges. This erlotinib side effect has not been previously reported in the medical literature.
期刊介绍：
The Connecticut State Medical Society (CSMS) is a federation of eight component county medical associations, with a total membership exceeding 7,000 physicians. CSMS itself is a constituent state entity of the American Medical Association. Founded by the physician-patriots of the American Revolution, the Society operates from a heritage of democratic principles embodied in its Charter and Bylaws. The base of all authority in CSMS is, of course, the individual physician member. It is the decisions of members in their own county associations that ultimately determine the nature of the Society"s policies and activities.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
