Influence of ibuprofen combined with corticotomy on tooth movement and alveolar bone remodeling in rats.

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC

ACS Applied Electronic Materials Pub Date : 2022-11-01 DOI:10.2319/021722-146.1

Chanakant Jindarojanakul, Bancha Samruajbenjakun

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引用次数: 3

Abstract

Objectives: To investigate the effects of corticotomy-assisted orthodontic tooth movement and administration of ibuprofen on tooth movement rate and alveolar bone response.

Materials and methods: A total of 78 adult male Wistar rats were randomly assigned to five groups: one baseline group (no treatment) and four experimental groups including orthodontic tooth movement only (OTM), orthodontic tooth movement with ibuprofen (OTMI), corticotomy-assisted orthodontic tooth movement (COTM), and corticotomy-assisted orthodontic tooth movement with ibuprofen (COTMI). Corticotomy was performed on a maxillary molar unilaterally. Nickel-titanium closed-coil springs generated a 10-gram force for maxillary first molar movement. The experimental drug groups received 15 mg/kg of ibuprofen, and the other groups received reverse osmosis water. Tooth movement and bone volume fraction were evaluated by micro-computed tomography on days 0, 7, 14, and 21.

Results: The corticotomy groups had statistically significantly higher tooth movement and lower bone volume fraction than the orthodontic groups (P < .05). The amount and rate of tooth movement were statistically significantly different between the OTM and OTMI groups, but not statistically significantly different in bone volume fraction. However, statistically significant differences were not observed in any measurements between the COTM and COTMI groups.

Conclusions: Ibuprofen during orthodontic tooth movement inhibited tooth movement and alveolar bone remodeling but had no effect on corticotomy-assisted orthodontic treatment.

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布洛芬联合皮质切开术对大鼠牙齿运动及牙槽骨重塑的影响。

目的:探讨皮质切开术辅助正畸牙齿移动和布洛芬对牙齿移动速度和牙槽骨反应的影响。材料与方法:78只成年雄性Wistar大鼠随机分为5组:1个基线组(未治疗)和4个实验组:仅正畸牙齿移动组(OTM)、布洛芬正畸牙齿移动组(OTMI)、皮质切开术辅助正畸牙齿移动组(COTM)和皮质切开术辅助布洛芬正畸牙齿移动组(COTMI)。单侧上颌磨牙行皮质切开术。镍钛闭合弹簧为上颌第一磨牙运动产生10克力。实验药物组给予15 mg/kg布洛芬，其余组给予反渗透水。在第0、7、14和21天通过显微计算机断层扫描评估牙齿运动和骨体积分数。结果:与正畸组相比，皮质切开术组牙齿移动量明显增加，骨体积分数明显降低(P <. 05)。OTM组和OTMI组的牙齿移动量和速度差异有统计学意义，而骨体积分数差异无统计学意义。然而，在COTM组和COTMI组之间的任何测量均未观察到统计学上的显著差异。结论:布洛芬在正畸牙齿移动时抑制牙齿移动和牙槽骨重塑，但对皮质切开术辅助正畸治疗无影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Electronic Materials Multiple-

CiteScore

7.20

自引率

4.30%

发文量

567

期刊介绍： ACS Applied Electronic Materials is an interdisciplinary journal publishing original research covering all aspects of electronic materials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials science, engineering, optics, physics, and chemistry into important applications of electronic materials. Sample research topics that span the journal's scope are inorganic, organic, ionic and polymeric materials with properties that include conducting, semiconducting, superconducting, insulating, dielectric, magnetic, optoelectronic, piezoelectric, ferroelectric and thermoelectric. Indexed/Abstracted： Web of Science SCIE Scopus CAS INSPEC Portico