Influence of ibuprofen combined with corticotomy on tooth movement and alveolar bone remodeling in rats.

IF 3 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Angle Orthodontist Pub Date : 2022-11-01 DOI:10.2319/021722-146.1

Chanakant Jindarojanakul, Bancha Samruajbenjakun

{"title":"Influence of ibuprofen combined with corticotomy on tooth movement and alveolar bone remodeling in rats.","authors":"Chanakant Jindarojanakul, Bancha Samruajbenjakun","doi":"10.2319/021722-146.1","DOIUrl":null,"url":null,"abstract":"Objectives: To investigate the effects of corticotomy-assisted orthodontic tooth movement and administration of ibuprofen on tooth movement rate and alveolar bone response.Materials and methods: A total of 78 adult male Wistar rats were randomly assigned to five groups: one baseline group (no treatment) and four experimental groups including orthodontic tooth movement only (OTM), orthodontic tooth movement with ibuprofen (OTMI), corticotomy-assisted orthodontic tooth movement (COTM), and corticotomy-assisted orthodontic tooth movement with ibuprofen (COTMI). Corticotomy was performed on a maxillary molar unilaterally. Nickel-titanium closed-coil springs generated a 10-gram force for maxillary first molar movement. The experimental drug groups received 15 mg/kg of ibuprofen, and the other groups received reverse osmosis water. Tooth movement and bone volume fraction were evaluated by micro-computed tomography on days 0, 7, 14, and 21.Results: The corticotomy groups had statistically significantly higher tooth movement and lower bone volume fraction than the orthodontic groups (P < .05). The amount and rate of tooth movement were statistically significantly different between the OTM and OTMI groups, but not statistically significantly different in bone volume fraction. However, statistically significant differences were not observed in any measurements between the COTM and COTMI groups.Conclusions: Ibuprofen during orthodontic tooth movement inhibited tooth movement and alveolar bone remodeling but had no effect on corticotomy-assisted orthodontic treatment.","PeriodicalId":50790,"journal":{"name":"Angle Orthodontist","volume":null,"pages":null},"PeriodicalIF":3.0000,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598854/pdf/i1945-7103-92-6-773.pdf","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Angle Orthodontist","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2319/021722-146.1","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}

引用次数: 3

Abstract

Objectives: To investigate the effects of corticotomy-assisted orthodontic tooth movement and administration of ibuprofen on tooth movement rate and alveolar bone response.

Materials and methods: A total of 78 adult male Wistar rats were randomly assigned to five groups: one baseline group (no treatment) and four experimental groups including orthodontic tooth movement only (OTM), orthodontic tooth movement with ibuprofen (OTMI), corticotomy-assisted orthodontic tooth movement (COTM), and corticotomy-assisted orthodontic tooth movement with ibuprofen (COTMI). Corticotomy was performed on a maxillary molar unilaterally. Nickel-titanium closed-coil springs generated a 10-gram force for maxillary first molar movement. The experimental drug groups received 15 mg/kg of ibuprofen, and the other groups received reverse osmosis water. Tooth movement and bone volume fraction were evaluated by micro-computed tomography on days 0, 7, 14, and 21.

Results: The corticotomy groups had statistically significantly higher tooth movement and lower bone volume fraction than the orthodontic groups (P < .05). The amount and rate of tooth movement were statistically significantly different between the OTM and OTMI groups, but not statistically significantly different in bone volume fraction. However, statistically significant differences were not observed in any measurements between the COTM and COTMI groups.

Conclusions: Ibuprofen during orthodontic tooth movement inhibited tooth movement and alveolar bone remodeling but had no effect on corticotomy-assisted orthodontic treatment.

查看原文本刊更多论文

布洛芬联合皮质切开术对大鼠牙齿运动及牙槽骨重塑的影响。

目的:探讨皮质切开术辅助正畸牙齿移动和布洛芬对牙齿移动速度和牙槽骨反应的影响。材料与方法:78只成年雄性Wistar大鼠随机分为5组:1个基线组(未治疗)和4个实验组:仅正畸牙齿移动组(OTM)、布洛芬正畸牙齿移动组(OTMI)、皮质切开术辅助正畸牙齿移动组(COTM)和皮质切开术辅助布洛芬正畸牙齿移动组(COTMI)。单侧上颌磨牙行皮质切开术。镍钛闭合弹簧为上颌第一磨牙运动产生10克力。实验药物组给予15 mg/kg布洛芬，其余组给予反渗透水。在第0、7、14和21天通过显微计算机断层扫描评估牙齿运动和骨体积分数。结果:与正畸组相比，皮质切开术组牙齿移动量明显增加，骨体积分数明显降低(P <. 05)。OTM组和OTMI组的牙齿移动量和速度差异有统计学意义，而骨体积分数差异无统计学意义。然而，在COTM组和COTMI组之间的任何测量均未观察到统计学上的显著差异。结论:布洛芬在正畸牙齿移动时抑制牙齿移动和牙槽骨重塑，但对皮质切开术辅助正畸治疗无影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Angle Orthodontist 医学-牙科与口腔外科

CiteScore

6.40

自引率

5.90%

发文量

审稿时长

3 months

期刊介绍： The Angle Orthodontist is the official publication of the Edward H. Angle Society of Orthodontists and is published bimonthly in January, March, May, July, September and November by The EH Angle Education and Research Foundation Inc. The Angle Orthodontist is the only major journal in orthodontics with a non-commercial, non-profit publisher -- The E. H. Angle Education and Research Foundation. We value our freedom to operate exclusively in the best interests of our readers and authors. Our website www.angle.org is completely free and open to all visitors.