Relationship between umbilical cord blood insulin-like growth factors and anthropometry in term newborns.

Te-Yu Hung, Chin-Chuan Lin, Yea-Shwu Hwang, Shio-Jean Lin, Yen-Yin Chou, Wen-Hui Tsai
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Abstract

Background: Birth size is associated with long-term morbidity. Insulin-like growth factor (IGF) system is the most important endocrine factor influencing fetal growth. During rapid somatic growth, free-to-total IGF-I ratio is increased, resulting in higher IGF-I bioavailability. The purpose of this study was to investigate the association of free-to-total IGF-I ratios, IGF-II, and IGF-binding protein (IGFBP)-3 umbilical cord levels with anthropometric data of term neonates.

Methods: Umbilical venous plasma samples were obtained from 95 term neonates and analyzed by enzyme-linked immunosorbent assay.

Results: The large-for-gestational age (LGA) neonates had higher free IGF-I, total IGF-I, and IGFBP-3 levels than small-for-gestational age (SGA) neonates (P < 0.01, 0.001, 0.01, respectively) and higher total IGF-I and IGFBP-3 levels than appropriate-for-gestational age (AGA) neonates (P < 0.05, 0.01, respectively). The free-to-total IGF-I ratios and IGF-II levels were not different among SGA, AGA, and LGA neonates. Free IGF-I, total IGF-I, and IGFBP-3 levels were positively correlated with birth weight (r = 0.34, P < 0.001; r = 0.41, P < 0.001; r = 0.25, P < 0.05, respectively). Multiple linear regression analyses revealed that only total IGF-I levels was the independent predictive variable for birth weight.

Conclusions: Our data suggest total IGF-I is the most important factor in the IGF system for determining fetal growth, at least near term gestation. Free-to-total IGF-I ratios may mostly be determined by total IGF-I. If birth size is associated with adult chronic metabolic diseases, total IGF-I may be involved in the pathogenesis.

足月新生儿脐带血胰岛素样生长因子与人体测量的关系。
背景:出生大小与长期发病率相关。胰岛素样生长因子(IGF)系统是影响胎儿生长的最重要的内分泌因子。在体细胞快速生长过程中,游离-总IGF-I比例增加,导致IGF-I的生物利用度提高。本研究的目的是研究足月新生儿脐带游离总IGF-I比率、IGF-II和igf结合蛋白(IGFBP)-3水平与人体测量数据的关系。方法:采用酶联免疫吸附法对95例足月新生儿脐静脉血浆进行分析。结果:大胎龄(LGA)新生儿游离IGF-I、总IGF-I、IGFBP-3水平高于小胎龄(SGA)新生儿(P分别< 0.01、0.001、0.01),总IGF-I、IGFBP-3水平高于适胎龄(AGA)新生儿(P分别< 0.05、0.01)。SGA、AGA和LGA新生儿的游离总IGF-I比率和IGF-II水平没有差异。游离IGF-I、总IGF-I和IGFBP-3水平与出生体重呈正相关(r = 0.34, P < 0.001;r = 0.41, P < 0.001;r = 0.25, P < 0.05)。多元线性回归分析显示,只有总IGF-I水平是出生体重的独立预测变量。结论:我们的数据表明,在IGF系统中,总IGF- 1是决定胎儿生长的最重要因素,至少在妊娠中期是如此。游离-总IGF-I比率可能主要由总IGF-I决定。如果出生尺寸与成人慢性代谢性疾病相关,igf - 1总量可能参与其发病机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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