The Reaching Phase of Feeding and Self-Care Actions Optimizes Action Observation Effects in Chronic Stroke Subjects.

IF 3.7 2区医学 Q1 CLINICAL NEUROLOGY

Neurorehabilitation and Neural Repair Pub Date : 2022-09-01 Epub Date: 2022-08-24 DOI:10.1177/15459683221110884

Marco Franceschini, Marco Ottaviani, Paola Romano, Michela Goffredo, Sanaz Pournajaf, Margherita Lofrumento, Stefania Proietti, Irma Sterpi, Enrica Tricomi, Peppino Tropea, Massimo Corbo, Luciano Fadiga, Francesco Infarinato

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引用次数: 2

Abstract

Background: The Action Observation Therapy (AOT) is a well-established post-stroke rehabilitation treatment based on the theoretical framework of the Mirror Neuron System (MNS) activation. However, AOT protocols are still heterogeneous in terms of video contents of observed actions.

Objective: The aim of this study was to analyze electroencephalographic (EEG) recordings in stroke patients during the observation of different videos of task-specific upper limb movements, and to define which category of actions can elicit a stronger cortical activation in the observer's brain.

Methods: Signals were analyzed from 19 chronic stroke subjects observing customized videos that represented 3 different categories of upper limb actions: Finalized Actions, Non-Finalized Actions, and Control Videos. The Event-Related Desynchronization in the µ and β bands was chosen to identify the involvement of the cerebral cortex: the area of the normalized power spectral density was calculated for each category and, deepening, for the reaching and completion sub-phases of Finalized Actions. For descriptive purposes, the time course of averaged signal power was described. The Kruskal-Wallis test (P < .05) was applied.

Results: The analysis showed a greater desynchronization when subjects observed Finalized Actions with respect to Non-Finalized in all recorded areas; Control videos provoked a synchronization in the same areas and frequency bands. The reaching phase of feeding and self-care actions evoked a greater suppression both in µ and β bands.

Conclusions: The observation of finalized arm movements seems to elicit the strongest activation of the MNS in chronic stroke patients. This finding may help the clinicians to design future AOT-based stroke rehabilitation protocols.

Clinical trial registration: Clinical Trial Registration-URL: http://www.clinicaltrials.gov. Unique identifier: NCT04047134.

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慢性脑卒中患者摄食与自我照顾动作到达期优化动作观察效果。

背景:动作观察疗法(AOT)是一种基于镜像神经元系统(MNS)激活理论框架的卒中后康复治疗方法。然而，在观察到的动作的视频内容方面，AOT协议仍然是异构的。目的:分析脑卒中患者在观看不同任务上肢运动视频时的脑电图记录，并确定哪一类动作能引起观察者大脑皮层更强的激活。方法:对19例慢性脑卒中患者的信号进行分析，观察表征3种不同类型上肢动作的定制视频:定型动作、非定型动作和控制视频。选择µ和β波段的事件相关去同步(event - associated desynsynchronization)来识别大脑皮层的参与:计算每个类别的归一化功率谱密度面积，并进一步计算最终动作的到达和完成子阶段。为了便于描述，我们描述了平均信号功率的时间过程。Kruskal-Wallis测试(P)结果:分析显示，当受试者在所有记录区域中观察到已完成的动作与未完成的动作时，非同步性更大;对照录像在同一地区和频段引起了同步。进食和自理动作到达期在µ和β波段均有较大的抑制。结论:在慢性脑卒中患者中，最终的手臂运动似乎引起了MNS最强的激活。这一发现可能有助于临床医生设计未来基于aot的卒中康复方案。临床试验注册:临床试验注册-网址:http://www.clinicaltrials.gov唯一标识符:NCT04047134。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurorehabilitation and Neural Repair 医学-康复医学

CiteScore

8.30

自引率

4.80%

发文量

审稿时长

6-12 weeks

期刊介绍： Neurorehabilitation & Neural Repair (NNR) offers innovative and reliable reports relevant to functional recovery from neural injury and long term neurologic care. The journal''s unique focus is evidence-based basic and clinical practice and research. NNR deals with the management and fundamental mechanisms of functional recovery from conditions such as stroke, multiple sclerosis, Alzheimer''s disease, brain and spinal cord injuries, and peripheral nerve injuries.