The pharmacogenetics of mycophenolate mofetil in Tunisian renal transplant patients.

IF 1.7 4区 医学 Q3 PHARMACOLOGY & PHARMACY
Personalized medicine Pub Date : 2022-09-01 Epub Date: 2022-06-30 DOI:10.2217/pme-2021-0092
Amani Abderahmene, Amel Ellouz, Dorra Amor, Marwa Ajmi, Yassine Khalij, Haithem Hamdouni, Wissal Sahtout, Awatef Azzabi, Asma Omezzine, Abdellatif Achour, Ali Bouslama
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引用次数: 0

Abstract

Aim: The effects of variants in IMPDH, UGT1A9, UGT1A8, UGT2B7 and SLCO1B1 genes on the efficacy and safety of mycophenolate mofetil (MMF) in the Tunisian population were investigated. Materials & methods: A total of 245 kidney transplant patients being treated with MMF were recruited and cotreated with cyclosporine or tacrolimus. Genotyping was performed using the polymerase chain reaction-restriction fragment length polymorphism method. MMF, cyclosporine and tacrolimus trough levels were measured by immunoassay. The AUC (AUC0-12hMPA) was estimated by a Bayesian method. Results: In the tacrolimus-treated group, anemia and diarrhea were associated with the UGT1A9-98C and UGT1A9-275T alleles, respectively (p < 0.05). In the cyclosporine-treated group, leukopenia was associated with the SLCO1B1-521T allele (p < 0.05). Both groups had an increased risk of rejection (p < 0.05) associated with the variant alleles of IMPDH2-3757T>C, UGT1A9-2152C>T and UGT1A9-275C>A and the common allele of SLCO1B1-388A>G. However, no significant association was found between the studied genotypes and AUC0-12hMPA or cotreatment levels. Conclusion: The results constitute preliminary evidence for the inclusion of the pharmacogenetics of MMF in kidney pretransplantation evaluations.

突尼斯肾移植患者霉酚酸酯的药物遗传学研究。
目的:研究突尼斯人群中IMPDH、UGT1A9、UGT1A8、UGT2B7和SLCO1B1基因变异对霉酚酸酯(MMF)疗效和安全性的影响。材料与方法:共招募245例接受MMF治疗的肾移植患者,并与环孢素或他克莫司联合治疗。采用聚合酶链反应-限制性片段长度多态性法进行基因分型。免疫法测定MMF、环孢素和他克莫司谷水平。采用贝叶斯方法估计AUC (AUC0-12hMPA)。结果:在他克莫司治疗组中,贫血和腹泻分别与UGT1A9-98C和UGT1A9-275T等位基因(p IMPDH2-3757T>C、UGT1A9-2152C>T和UGT1A9-275C>A以及SLCO1B1-388A>G)相关。然而,所研究的基因型与AUC0-12hMPA或共处理水平之间没有显著关联。结论:该结果为MMF的药物遗传学纳入肾移植前评估提供了初步证据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Personalized medicine
Personalized medicine 医学-药学
CiteScore
3.30
自引率
4.30%
发文量
49
审稿时长
6-12 weeks
期刊介绍: Personalized Medicine (ISSN 1741-0541) translates recent genomic, genetic and proteomic advances into the clinical context. The journal provides an integrated forum for all players involved - academic and clinical researchers, pharmaceutical companies, regulatory authorities, healthcare management organizations, patient organizations and others in the healthcare community. Personalized Medicine assists these parties to shape thefuture of medicine by providing a platform for expert commentary and analysis. The journal addresses scientific, commercial and policy issues in the field of precision medicine and includes news and views, current awareness regarding new biomarkers, concise commentary and analysis, reports from the conference circuit and full review articles.
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