Age Differences in Naloxone Reversibility of Electroacupuncture on the Jaw Opening Reflex in Rats.

IF 0.9 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Acupuncture and Meridian Studies Pub Date : 2021-08-31 DOI:10.51507/j.jams.2021.14.4.167

Hiromi Yamashita, Jorge Luis Lopes Zeredo, Kazuo Toda

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引用次数: 0

Abstract

Background: Electroacupuncture is one of the most popular physical treatments for clinical pain, but the potential influence of a patient's age on the effectiveness of electroacupuncture treatment has not been clearly established. Objectives: The present study aimed to detect a potential difference in electroacupuncture- induced analgesia between juvenile and adult rats.

Methods: In this study, we investigated the effects of electroacupuncture treatment on the nociceptive jaw-opening reflex evoked by tooth-pulp stimulation in juvenile and adult rats.

Results: Our results showed there were age differences in electroacupuncture-induced analgesic effects in rats, especially with naloxone antagonization. The ratio of naloxonereversibility against electroacupuncture analgesia was greater in adult rats than in juvenile rats.

Conclusion: These results suggest that electroacupuncture analgesia is produced mainly by the non-opioid system in juvenile rats and by the opioid system in adult rats.

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电针纳洛酮可逆性对大鼠开口反射的年龄差异。

背景:电针是治疗临床疼痛最常用的物理疗法之一，但患者年龄对电针治疗效果的潜在影响尚未明确。目的:研究电针镇痛在幼年大鼠和成年大鼠之间的电位差异。方法:研究电针治疗对幼鼠和成年大鼠牙髓刺激引起的伤害性开颌反射的影响。结果:电针对大鼠的镇痛作用存在年龄差异，尤其是对纳洛酮的拮抗作用。成年大鼠对电针镇痛的纳洛酮可逆性比幼年大鼠大。结论:电针镇痛主要由幼年大鼠的非阿片系统产生，成年大鼠的阿片系统产生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Acupuncture and Meridian Studies INTEGRATIVE & COMPLEMENTARY MEDICINE-

CiteScore

1.50

自引率

10.00%

发文量

审稿时长

12 weeks

期刊介绍： The Journal of Acupuncture and Meridian Studies is a quarterly, peer-reviewed journal featuring high-quality studies related to basic and clinical acupuncture and meridian research. It also includes new paradigm of integrative research, covering East–West and traditional–modern medicine. Manuscripts should fall into one of the categories: topical review, original research paper, brief ... click here for full Aims & Scope The Journal of Acupuncture and Meridian Studies is a quarterly, peer-reviewed journal featuring high-quality studies related to basic and clinical acupuncture and meridian research. It also includes new paradigm of integrative research, covering East–West and traditional–modern medicine.