Oxana Semyachkina-Glushkovskaya, Inna Blokhina, Nikita Navolokin, Arina Evsukova, Georgy Karandin, Alexander Khorovodov, Andrey Terskov, Ivan Fedosov, Alexander Dubrovsky, Maria Tzoy, Vasily Ageev, Ilana Agranovich, Valeria Telnova, Anna Tsven, Jürgen Kurths
{"title":"GB20 Pharmacopuncture As a Potential Method for Brain Drug Delivery via the Perivascular Spaces.","authors":"Oxana Semyachkina-Glushkovskaya, Inna Blokhina, Nikita Navolokin, Arina Evsukova, Georgy Karandin, Alexander Khorovodov, Andrey Terskov, Ivan Fedosov, Alexander Dubrovsky, Maria Tzoy, Vasily Ageev, Ilana Agranovich, Valeria Telnova, Anna Tsven, Jürgen Kurths","doi":"10.51507/j.jams.2022.15.1.43","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The development of new methods of drug brain delivery is a crucial step for the effective therapy of the brain diseases. Pharma- and acupuncture are the forms of alternative therapy of the brain pathology, including an increase in the permeability of blood-brain barrier. However, the mechanisms of pharma- and acupuncture-mediated effects on the brain physiology remain not fully understood.</p><p><strong>Results: </strong>This pilot study on healthy mice clearly demonstrates the Evans Blue spreading in the mouse head and in the brain via the perivascular spaces (PVSs) of the trigeminal structure and the cribriform plate after the dye injection into the Feng Chi point (Galbladder 20, GB20).</p><p><strong>Conclusion: </strong>These results suggest that pharmacopuncture at GB20 can be a perspective method for brain drug delivery via PVSs.</p>","PeriodicalId":46854,"journal":{"name":"Journal of Acupuncture and Meridian Studies","volume":null,"pages":null},"PeriodicalIF":0.9000,"publicationDate":"2022-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Acupuncture and Meridian Studies","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.51507/j.jams.2022.15.1.43","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"INTEGRATIVE & COMPLEMENTARY MEDICINE","Score":null,"Total":0}
引用次数: 0
Abstract
Background: The development of new methods of drug brain delivery is a crucial step for the effective therapy of the brain diseases. Pharma- and acupuncture are the forms of alternative therapy of the brain pathology, including an increase in the permeability of blood-brain barrier. However, the mechanisms of pharma- and acupuncture-mediated effects on the brain physiology remain not fully understood.
Results: This pilot study on healthy mice clearly demonstrates the Evans Blue spreading in the mouse head and in the brain via the perivascular spaces (PVSs) of the trigeminal structure and the cribriform plate after the dye injection into the Feng Chi point (Galbladder 20, GB20).
Conclusion: These results suggest that pharmacopuncture at GB20 can be a perspective method for brain drug delivery via PVSs.
期刊介绍：
The Journal of Acupuncture and Meridian Studies is a quarterly, peer-reviewed journal featuring high-quality studies related to basic and clinical acupuncture and meridian research. It also includes new paradigm of integrative research, covering East–West and traditional–modern medicine. Manuscripts should fall into one of the categories: topical review, original research paper, brief ... click here for full Aims & Scope The Journal of Acupuncture and Meridian Studies is a quarterly, peer-reviewed journal featuring high-quality studies related to basic and clinical acupuncture and meridian research. It also includes new paradigm of integrative research, covering East–West and traditional–modern medicine.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
