Dynamic changes of serum cytokines in acute paraquat poisoning and changes in patients' immune function

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Huimin Yuan, Qian Liu, Yulan Yu
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Abstract

Acute paraquat poisoning is due to the extremely severe toxicity of paraquat. After paraquat enters the human body, it will cause rapid changes in the human body system. Since paraquat poisoning will quickly invade the organs of the whole body, it may cause damage to the functions of multiple organs in the poisoned patient. The liver organ is the most important detoxification site for the human body, so the damage to the liver of the patient is more obvious. This article discovers and observes the structure of paraquat and the dynamic changes of serum cytokines in patients with paraquat poisoning through the clinical phenomenon of paraquat poisoning, and the related changes of human serum cells after the subjects took paraquat and the changes of cell dynamic factors after different doses of paraquat entered the human body were analysed. At the same time, the changes in the immune function of the body of different groups of people were also observed. The experimental results in this article show that according to the intake of paraquat, the severity of poisoning patients will be mild, moderate, severe and outbreak poisoning. Among them, the dose for adults who cannot be treated for prognosis is 10 ml.

Abstract Image

急性百草枯中毒患者血清细胞因子的动态变化及免疫功能的变化
急性百草枯中毒是由于百草枯的毒性极其严重。百草枯进入人体后,会引起人体系统的快速变化。由于百草枯中毒会迅速侵入全身脏器,可能对中毒患者的多脏器功能造成损害。肝器官是人体最重要的排毒部位,因此对患者肝脏的损害更为明显。本文通过百草枯中毒的临床现象,发现并观察了百草枯中毒患者体内的百草枯结构和血清细胞因子的动态变化,并分析了受试者服用百草枯后人体血清细胞的相关变化以及不同剂量的百草枯进入人体后细胞动态因子的变化。同时,还观察了不同人群机体免疫功能的变化。本文的实验结果表明,根据百草枯的摄入量,中毒患者的严重程度将分为轻度、中度、重度和暴发中毒。其中,不能治疗预后的成人剂量为10ml。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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