Relationship of zinc level with pathogenetically significant homeostasis disorders in severely burned patients.

Q4 Health Professions

Klinichescheskaya Laboratornaya Diagnostika Pub Date : 2022-06-20 DOI:10.51620/0869-2084-2022-67-6-330-333

O V Kostina, V I Zagrekov, M V Presnyakova, A S Pushkin, M Yu Lebedev, V I Ashkinazi

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引用次数: 2

Abstract

The aim of the study was to assess the zinc content and identify the relationship between the concentration of this element and changes in the biochemical status of patients and markers of inflammation during burn shock. We examined 23 patients aged 45.3±16.1 years with burns of I-II-III degree, area of 31-80%. The serum concentrations of zinc, albumin, interleukin-6, C-reactive protein (CRP), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were determined. The majority of patients (21/23) had severe hypocincemia, correlated with burn area (r=-0.53; p=0.008). A decrease in zinc levels during burn shock was associated with the development of hypoalbuminemia (r=0.52, p=0.01). The association of deviations in ALT and AST activity with changes in zinc concentration was revealed (-0.59<γ<-0.61, 0.008

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重度烧伤患者锌水平与病理意义显著的体内平衡紊乱的关系。

该研究的目的是评估锌含量，并确定这种元素的浓度与烧伤休克期间患者生化状态和炎症标志物的变化之间的关系。本组患者23例，年龄45.3±16.1岁，烧伤程度为I-II-III度，面积为31-80%。测定血清锌、白蛋白、白细胞介素-6、c反应蛋白(CRP)、丙氨酸转氨酶(ALT)和天冬氨酸转氨酶(AST)的浓度。大多数患者(21/23)有严重低血血症，与烧伤面积相关(r=-0.53;p = 0.008)。烧伤休克期间锌水平的降低与低白蛋白血症的发生有关(r=0.52, p=0.01)。ALT和AST活性偏差与锌浓度变化的相关性为(-0.59)

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来源期刊

Klinichescheskaya Laboratornaya Diagnostika Health Professions-Medical Laboratory Technology

CiteScore

0.90

自引率

0.00%

发文量

110

期刊介绍： The journal deals with theoretical and practical problems of clinical laboratory diagnosis, publishes editorial articles, reviews of literature, original articles, short reports, discussions, book reviews, current events, materials which may assist the practitioners, methods of laboratory investigations used in medicine, materials on the results of practical application of new methods of investigation in the following fields of clinical laboratory diagnosis: hematology, cytology, coagulation, biochemistry, immunology.