Impact of community-based exercise on fatigue in early breast cancer survivors: identifying potential determinants of change.

IF 2.9
Breast cancer (Tokyo, Japan) Pub Date : 2022-11-01 Epub Date: 2022-06-24 DOI:10.1007/s12282-022-01380-y
Chad W Wagoner, Jordan T Lee, Erik D Hanson, Zachary Y Kerr, Kirsten A Nyrop, Hyman B Muss, Claudio L Battaglini
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Abstract

Background: Exercise has been shown to reduce fatigue in early breast cancer survivors (EBCS), though it is unclear if these results translate to community-based exercise settings. Mechanisms that influence changes in fatigue seen after exercise are also poorly understood. This study sought to evaluate the impact of community-based exercise and identify associations of fatigue in EBCS.

Methods: Twenty-nine EBCS and 13 non-cancer controls (CON) enrolled. Pre/post-intervention measurements included measures of fitness/function, balance, and adherence/compliance as well as self-reported measures of fatigue, health-related quality of life (HRQOL), well-being, self-efficacy, and physical activity. Both groups participated in a supervised 16-week aerobic + resistance exercise intervention. A mixed model ANOVA and Cohen's D effect size assessed fatigue changes, and univariable linear regressions identified fatigue associations.

Results: Fatigue improved for EBCS (- 2.6, Cohen's D = 0.51) but not CON (0.0, Cohen's D = 0.02); no interaction effect was observed. Post-intervention fatigue in EBCS was associated with better QOL (R2 = 0.387; p < 0.01), depression (R2 = 0.251; p < 0.01), self-efficacy, (R2 = 0.453; p < 0.01), outcome expectations from exercise (R2 = 0.254; p < 0.01), balance (R2 = 0.167; p < 0.05), and the 6-minute walk test (R2 = 0.193; p < 0.05). EBCS improvements in fatigue were associated with improvements in self-reported physical health (R2 = 0.425; p < 0.01), depression (R2 = 0.233; p < 0.01), pain (R2 = 0.157; p < 0.05), outcome expectations from exercise (R2 = 0.420; p < 0.01), and the 6-minute walk test (R2 = 0.172; p < 0.05). Less fatigue in the CON group was shown be associated with better sleep quality (R2 = 0.309; p < 0.05) and pain (R2 = 0.259; p < 0.05).

Conclusion: Community-based exercise appears beneficial for alleviating fatigue in EBCS. These improvements may be driven by parallel improvements in psychosocial outcomes and objectively measured functional outcomes.

社区运动对早期乳腺癌幸存者疲劳的影响:确定改变的潜在决定因素。
背景:运动已被证明可以减少早期乳腺癌幸存者(EBCS)的疲劳,尽管尚不清楚这些结果是否适用于社区运动环境。影响运动后疲劳变化的机制也知之甚少。本研究旨在评估社区运动的影响,并确定EBCS中疲劳的关联。方法:纳入29例EBCS和13例非癌对照(CON)。干预前/干预后测量包括健康/功能、平衡、依从性/依从性以及疲劳、健康相关生活质量(HRQOL)、幸福感、自我效能和身体活动的自我报告测量。两组都参加了为期16周的有氧+阻力运动干预。混合模型方差分析和科恩D效应大小评估疲劳变化,单变量线性回归确定疲劳关联。结果:EBCS组疲劳改善(- 2.6,Cohen’s D = 0.51), CON组无改善(0.0,Cohen’s D = 0.02);未观察到相互作用效应。EBCS干预后疲劳与较好的生活质量相关(R2 = 0.387;p 2 = 0.251;p 2 = 0.453;p 2 = 0.254;p 2 = 0.167;p 2 = 0.193;p 2 = 0.425;p 2 = 0.233;p 2 = 0.157;p 2 = 0.420;p 2 = 0.172;p 2 = 0.309;p 2 = 0.259;结论:社区运动有助于缓解EBCS患者的疲劳。这些改善可能是由社会心理结果和客观测量的功能结果的平行改善所驱动的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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