Age- and sex-related differences in the retinal capillary plexus in healthy Chinese adults.

IF 4.1 1区医学 Q1 OPHTHALMOLOGY

Eye and Vision Pub Date : 2022-10-01 DOI:10.1186/s40662-022-00307-0

Binbin Su, Xiaoxuan Zhu, Kai Yang, Yunfan Xiao, Chunmei Li, Keai Shi, Jia Qu, Fan Lu, Ming Li, Lele Cui

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引用次数: 3

Abstract

Background: To assess age- and sex-related changes in the superficial retinal capillary plexus (SCP) and deep retinal capillary plexus (DCP) in healthy Chinese adults.

Methods: In this cross-sectional study, all data were derived from the community-based Jidong Eye Cohort Study. Participants underwent optical coherence tomography angiography (OCTA) and other ocular and systemic examinations. The vessel densities of the whole measured area, parafovea, and four quadrants in the SCP and DCP were measured.

Results: We recruited 1036 eyes of 1036 healthy participants; the mean age was 40.4 ± 9.8 years, and 449 (43.3%) participants were males. The SCP and DCP vessel densities in all regions, except for temporal and nasal regions in the SCP, non-linearly decreased with age. The DCP vessel densities began to decrease at approximately 35 years of age, while the SCP vessel densities began to decrease at approximately 40 years of age. The DCP vessel densities decreased more rapidly than the SCP vessel densities at 35-50 years of age. The DCP vessel densities remained stable or slightly decreased after the age of 50 years in females, while those decreased linearly in most regions in males.

Conclusions: The retinal vessel density decreased earlier and more rapidly in the DCP than in the SCP, and the effect of aging on the DCP vessel density was sex-dependent. Our findings suggest that age and sex should be considered when interpreting clinical quantitative OCTA data.

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中国健康成人视网膜毛细血管丛的年龄和性别差异

背景:评估中国健康成人视网膜浅毛细血管丛(SCP)和视网膜深毛细血管丛(DCP)的年龄和性别相关变化。方法:在本横断面研究中，所有数据均来自基于社区的冀东眼队列研究。参与者接受了光学相干断层血管造影(OCTA)和其他眼部和全身检查。测量SCP和DCP的整个测量区域、准中央和四个象限的血管密度。结果:我们招募了1036名健康参与者的1036只眼睛;平均年龄40.4±9.8岁，男性449人(43.3%)。除颞部和鼻部外，其余部位的血管密度随年龄呈非线性下降。DCP血管密度在大约35岁时开始下降，而SCP血管密度在大约40岁时开始下降。35 ~ 50岁时，DCP血管密度比SCP血管密度下降更快。50岁后，女性DCP血管密度保持稳定或略有下降，而男性DCP血管密度在大多数地区呈线性下降。结论:DCP患者视网膜血管密度下降早于SCP患者，且年龄对DCP血管密度的影响具有性别依赖性。我们的研究结果表明，在解释临床定量OCTA数据时应考虑年龄和性别。

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来源期刊

Eye and Vision OPHTHALMOLOGY-

CiteScore

8.60

自引率

2.40%

发文量

审稿时长

15 weeks

期刊介绍： Eye and Vision is an open access, peer-reviewed journal for ophthalmologists and visual science specialists. It welcomes research articles, reviews, methodologies, commentaries, case reports, perspectives and short reports encompassing all aspects of eye and vision. Topics of interest include but are not limited to: current developments of theoretical, experimental and clinical investigations in ophthalmology, optometry and vision science which focus on novel and high-impact findings on central issues pertaining to biology, pathophysiology and etiology of eye diseases as well as advances in diagnostic techniques, surgical treatment, instrument updates, the latest drug findings, results of clinical trials and research findings. It aims to provide ophthalmologists and visual science specialists with the latest developments in theoretical, experimental and clinical investigations in eye and vision.