Contribution of ZBTB20 Polymorphisms to Esophageal Cancer Risk Among the Chinese Han Population.

Pharmacogenomics and Personalized Medicine Pub Date : 2022-09-20 eCollection Date: 2022-01-01 DOI:10.2147/PGPM.S370963

Shuyong Yu, Guihong Yuan, Feixiang Hu, Yongyu Li, Zhuang Chen, Ronglin Zhang, Ping Li, Zhaowei Chen, Jian Song

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引用次数: 1

Abstract

Background: ZBTB20 was overexpressed in esophageal cancer (EC). The study aimed to identify genotypes of ZBTB20 polymorphisms and their correlation with EC occurrence in a Chinese Han population.

Methods: Four single nucleotide polymorphisms (SNPs) in ZBTB20 were randomly selected for genotyping through Agena MassARRAY system among 525 EC patients and 522 healthy controls. Multiple genetic models were applied to assess the association of ZBTB20 polymorphisms with EC susceptibility by calculating odds ratios (ORs) with 95% confidence intervals (CIs).

Results: Rs10934270 was associated with lower EC susceptibility (OR = 0.64, p = 0.004) with statistical power >90% in overall analysis. Specifically, the correlation of rs10934270 with EC susceptibility was found in subgroups including patients with esophageal squamous cell carcinoma (ESCC), males, subjects aged ≤65 years, subjects with BMI ≤ 24 kg/m², and smokers. Rs9841504 might be a risk-increasing factor for ESCC. Moreover, rs9288999 in subjects aged ≤65 years and rs73230612 in females were related to lower EC risk.

Conclusion: Our research is the first to report that ZBTB20 rs10934270 is associated with reduced EC susceptibility in the Chinese Han population. These data provide a scientific basis for understanding the influence of the ZBTB20 gene on EC occurrence.

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中国汉族人群中ZBTB20多态性对食管癌风险的贡献

背景:ZBTB20在食管癌(EC)中过表达。本研究旨在确定中国汉族人群ZBTB20基因型多态性及其与EC发生的相关性。方法:采用Agena MassARRAY系统，随机抽取525例EC患者和522例健康对照者的ZBTB20基因4个单核苷酸多态性进行分型。通过计算95%置信区间(ci)的优势比(ORs)，应用多重遗传模型评估ZBTB20多态性与EC易感性的关联。结果:Rs10934270与较低的EC易感性相关(OR = 0.64, p = 0.004)，总体分析统计能力>90%。具体而言，rs10934270与EC易感性在食管鳞状细胞癌(ESCC)患者、男性、年龄≤65岁、BMI≤24 kg/m2和吸烟者等亚组中均存在相关性。Rs9841504可能是ESCC的风险增加因素。年龄≤65岁受试者的rs9288999和女性受试者的rs73230612与较低的EC风险相关。结论:我们的研究首次报道了ZBTB20 rs10934270与中国汉族人群EC易感性降低相关。这些数据为了解ZBTB20基因对EC发生的影响提供了科学依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Pharmacogenomics and Personalized Medicine

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