Association of CYP7A1 and CYP2E1 Polymorphisms with Type 2 Diabetes in the Chinese Han Populations.

Pharmacogenomics and Personalized Medicine Pub Date : 2022-09-21 eCollection Date: 2022-01-01 DOI:10.2147/PGPM.S367806

Lihong Zhang, Jingjing Tang, Yindi Wang, Xiang Wang, Fang Wang

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引用次数: 2

Abstract

Background: Type 2 diabetes mellitus (T2DM) is caused by diverse environmental and genetic risk factors. Previous studies have reported that cytochrome P450 (CYP) is a promising gene for T2DM. Therefore, we aimed to determine the effects of CYP7A1 and CYP2E1 polymorphisms on T2DM susceptibility among the Chinese Han population.

Methods: A case-control study was conducted to assess the potential relationship of four polymorphisms (rs8192879, rs12542233, rs2070672 and rs2515641) with T2DM susceptibility in the Chinese population, involving 512 T2DM patients and 515 age- and gender-matched healthy individuals. We used the Agena MassARRAY platform to detect CYP7A1 and CYP2E1 polymorphisms. The relationship between genetic polymorphisms and T2DM risk was evaluated using odds ratios (ORs) and 95% confidence intervals (CIs) in various genetic models.

Results: After adjusting for age and gender, rs12542233 in the CYP7A1 gene was significantly associated with decreased T2DM risk (recessive: OR = 0.67, 95% CI = 0.49-0.91, p = 0.012; after FDR correction, p = 0.048). The CYP7A1 rs12542233 was associated with a reduced risk of T2DM in people over 59 years of age (p = 0.010). In the population with BMI ≤ 24 kg/m², CYP7A1 rs12542233 was associated with an increased risk of T2DM (p < 0.05). In the population with BMI > 24 kg/m², CYP2E1 rs2515641 can significantly reduce the risk of T2DM (p < 0.05). And rs8192879, rs2070672 and rs2515641 could significantly increase the risk of diabetes retinopathy in T2DM patients (p < 0.05). Furthermore, the T_rs8192879C_rs12542233 haplotype was significantly associated with T2DM (p = 0.019).

Conclusion: CYP7A1 and CYP2E1 polymorphisms may contribute to T2DM susceptibility in the Chinese Han population, especially in stratified analysis.

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CYP7A1和CYP2E1多态性与中国汉族2型糖尿病的关系

背景:2型糖尿病(T2DM)是由多种环境和遗传危险因素引起的。先前的研究报道细胞色素P450 (CYP)是T2DM的一个有希望的基因。因此，我们旨在确定CYP7A1和CYP2E1多态性对中国汉族人群2型糖尿病易感性的影响。方法:通过病例对照研究，评估中国人群中4种多态性(rs8192879、rs12542233、rs2070672和rs2515641)与T2DM易感性的潜在关系，纳入512名T2DM患者和515名年龄和性别匹配的健康个体。我们使用Agena MassARRAY平台检测CYP7A1和CYP2E1多态性。在各种遗传模型中，使用比值比(ORs)和95%置信区间(CIs)评估遗传多态性与2型糖尿病风险之间的关系。结果:在调整年龄和性别后，CYP7A1基因rs12542233与T2DM风险降低显著相关(隐性:OR = 0.67, 95% CI = 0.49-0.91, p = 0.012;经FDR校正后，p = 0.048)。CYP7A1 rs12542233与59岁以上人群T2DM风险降低相关(p = 0.010)。在BMI≤24 kg/m2的人群中，CYP7A1 rs12542233与T2DM风险增加相关(p < 0.05)。在BMI > 24 kg/m2人群中，CYP2E1 rs2515641可显著降低T2DM发病风险(p < 0.05)。rs8192879、rs2070672、rs2515641可显著增加T2DM患者发生糖尿病视网膜病变的风险(p < 0.05)。此外，Trs8192879Crs12542233单倍型与T2DM显著相关(p = 0.019)。结论:CYP7A1和CYP2E1多态性可能与中国汉族人群的T2DM易感性有关，特别是在分层分析中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Pharmacogenomics and Personalized Medicine

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